Evolutionary Optimization of Speed and Accuracy of Decoding on the Ribosome

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2011 Sep 21

PMID 21930591

Citations 79

Authors

Ingo Wohlgemuth

Corinna Pohl

Joerg Mittelstaet

Andrey L Konevega

Marina V Rodnina

Affiliations

Soon will be listed here.

Abstract

Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living cells, the quality control of translation, and the evolution of ribosomes. The ribosome developed complex mechanisms that allow for a uniform recognition and selection of any cognate aminoacyl-tRNA (aa-tRNA) and discrimination against any near-cognate aa-tRNA, regardless of the nature or position of the mismatch. This review describes the principles of the selection-kinetic partitioning and induced fit-and discusses the relationship between speed and accuracy of decoding, with a focus on bacterial translation. The translational machinery apparently has evolved towards high speed of translation at the cost of fidelity.

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