A Polymorphism in the Leptin Gene Promoter is Associated with Anemia in Patients with HIV Disease

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2011 Sep 20

PMID 21926355

Citations 1

Authors

Gary J Vanasse

Jee-Yeong Jeong

Janet Tate

Harini Bathulapalli

Damon Anderson

Hanno Steen

Mark Fleming

Kristin Mattocks

Amalio Telenti

Jacques Fellay

Amy C Justice

Nancy Berliner

Affiliations

Soon will be listed here.

Abstract

To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.

Citing Articles

Anemia in the elderly.

Berliner N Trans Am Clin Climatol Assoc. 2013; 124:230-7.

PMID: 23874029 PMC: 3715932.

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