Autoantibody Formation in Human and Rat Studies of Chronic Rejection and Primary Graft Dysfunction

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2011 Sep 20

PMID 21925897

Citations 7

Authors

David S Wilkes

Affiliations

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Abstract

Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation.

Citing Articles

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Antibody-Mediated Rejection: Diagnosis and Treatment.

Halverson L, Hachem R Clin Chest Med. 2023; 44(1):95-103.

PMID: 36774172 PMC: 10148231. DOI: 10.1016/j.ccm.2022.10.008.

IL-1β-dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction.

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Clinical relevance of lung-restricted antibodies in lung transplantation.

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Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection.

Gauthier J, Ruiz-Perez D, Li W, Hachem R, Puri V, Gelman A Transplantation. 2018; 102(9):1459-1466.

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