The Nucleosome Remodeling Factor

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2011 Sep 17

PMID 21920360

Citations 51

Authors

Suehyb G Alkhatib

Joseph W Landry

Affiliations

Soon will be listed here.

Abstract

An essential component of the chromatin remodeling machinery is NURF (Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF has many important functions in chromatin biology including regulating transcription, establishing boundary elements, and promoting higher order chromatin structure. Since NURF is essential to many aspects of chromatin biology, knowledge of its function is required to fully understand how the genome is regulated. This review will summarize what is currently known of its biological functions, conservation in the most prominent model organisms, biochemical functions as a nucleosome remodeling enzyme, and its possible relevance to human cancer.

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