Infected Pancreatic Necrosis: Not Necessarily a Late Event in Acute Pancreatitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 Sep 14

PMID 21912463

Citations 8

Authors

Maxim S Petrov

Vincent Chong

John A Windsor

Affiliations

Soon will be listed here.

Abstract

It is widely believed that infection of pancreatic necrosis is a late event in the natural course of acute pancreatitis. This paper discusses the available data on the timing of pancreatic infection. It appears that infected pancreatic necrosis occurs early in almost a quarter of patients. This has practical implications for the type, timing and duration of preventive strategies used in these patients. There are also implications for the classification of severity in patients with acute pancreatitis. Given that the main determinants of severity are both local and systemic complications and that they can occur both early and late in the course of acute pancreatitis, the classification of severity should be based on their presence or absence rather than on when they occur. To do otherwise, and in particular overlook early infected pancreatic necrosis, may lead to a misclassification error and fallacies of clinical studies in patients with acute pancreatitis.

Citing Articles

When to Intervene in Acute Necrotizing Pancreatitis: A Narrative Review of the Optimal Timing for Intervention Strategies.

Paramythiotis D, Karlafti E, Tsavdaris D, Giakoustidis A, Panidis S, Ioannidis A Medicina (Kaunas). 2024; 60(10).

PMID: 39459378 PMC: 11509130. DOI: 10.3390/medicina60101592.

Safety and clinical outcomes of early dual modality drainage (< 28 days) compared to later drainage of pancreatic necrotic fluid collections: a propensity score-matched study.

Bomman S, Sanders D, Coy D, La Selva D, Pham Q, Zehr T Surg Endosc. 2022; 37(2):902-911.

PMID: 36038648 DOI: 10.1007/s00464-022-09561-8.

The clinical outcome from early versus delayed minimally invasive intervention for infected pancreatic necrosis: a systematic review and meta-analysis.

Gao L, Zhang H, Li G, Ye B, Zhou J, Tong Z J Gastroenterol. 2022; 57(6):397-406.

PMID: 35488104 DOI: 10.1007/s00535-022-01876-6.

Percutaneous biopsy and drainage of the pancreas.

Planz V, Galgano S Abdom Radiol (NY). 2021; 47(8):2584-2603.

PMID: 34410433 PMC: 8375282. DOI: 10.1007/s00261-021-03244-z.

Occurrence and Risk Factors of Infected Pancreatic Necrosis in Intensive Care Unit-Treated Patients with Necrotizing Severe Acute Pancreatitis.

Husu H, Valkonen M, Leppaniemi A, Mentula P J Gastrointest Surg. 2021; 25(9):2289-2298.

PMID: 33987740 PMC: 8118108. DOI: 10.1007/s11605-021-05033-x.

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