Ribosomal Mutations As the Main Cause of Macrolide Resistance in Campylobacter Jejuni and Campylobacter Coli

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2011 Sep 14

PMID 21911571

Citations 16

Authors

Mirva Lehtopolku

Pirkko Kotilainen

Marjo Haanpera-Heikkinen

Ulla-Maija Nakari

Marja-Liisa Hanninen

Pentti Huovinen

Anja Siitonen

Erkki Eerola

Jari Jalava

Antti J Hakanen

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.

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