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Association of Chinese Medicine Constitution Susceptibility to Diabetic Nephropathy and Transforming Growth Factor-β1 (T869C) Gene Polymorphism

Overview
Journal Chin J Integr Med
Date 2011 Sep 13
PMID 21910069
Citations 7
Authors
Xin Mou
Wen-Hong Liu
Dan-Yang Zhou
Ying-Hui Liu
Yong-Bin Hu
Guo-Ling Ma
Cheng-Min Shou
Jia-Wei Chen
Jin-Xi Zhao
Affiliations
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Abstract

Objective: To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism.

Methods: TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms.

Results: The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group, and CC/CT genotypes than the T2DM group [CC, CT, TT (DN group): 88, 87, 5 (cases) versus (T2DM group) 71, 73, 36 (cases), P<0.05]. The phlegm-dampness constitution, damp-heat constitution, and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism.

Conclusion: Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism, a potential predictor of susceptibility to DN in T2DM patients.

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Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population.

Zhou T, Li H, Zhong H, Zhong Z BMC Med Genet. 2018; 19(1):201.

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Different Risk Indictors of Diabetic Nephropathy in Transforming Growth Factor-beta1 T869C CC/CT Genotype and TT Genotype.

Mou X, Liu Y, Zhou D, Hu Y, Ma G, Shou C Iran J Public Health. 2016; 45(6):761-7.

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Association of transforming growth factor-β1 polymorphisms with the risk of diabetes mellitus.

Mao S, Zhang J, Zhao M, Zhang Y Int J Clin Exp Med. 2016; 8(11):21886-92.

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Yang Deficiency Body Constitution Acts as a Predictor of Diabetic Retinopathy in Patients with Type 2 Diabetes: Taichung Diabetic Body Constitution Study.

Lee C, Li T, Tsai C, Lin S, Lee I, Lee H Evid Based Complement Alternat Med. 2015; 2015:940898.

PMID: 26167195 PMC: 4475744. DOI: 10.1155/2015/940898.

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