The Role of Annexin A2 in Tumorigenesis and Cancer Progression

Overview

Journal Cancer Microenviron

Publisher Springer

Specialty Oncology

Date 2011 Sep 13

PMID 21909879

Citations 125

Authors

Noor A Lokman

Miranda P Ween

Martin K Oehler

Carmela Ricciardelli

Affiliations

Soon will be listed here.

Abstract

Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular functions, including angiogenesis, proliferation, apoptosis, cell migration, invasion and adhesion. Annexin A2 binds with plasminogen and tissue plasminogen activator on the cell surface, which leads to the conversion of plasminogen to plasmin. Plasmin is a serine protease which plays a key role in the activation of metalloproteinases and degradation of extracellular matrix components essential for metastatic progression. We have recently found that both annexin A2 and plasmin are increased in conditioned media of co cultured ovarian cancer and peritoneal cells. Our studies suggest that annexin A2 is part of a tumor-host signal pathway between ovarian cancer and peritoneal cells which promotes ovarian cancer metastasis. Accumulating evidence suggest that interactions between annexin A2 and its binding proteins play an important role in the tumor microenvironment and act together to enhance cancer metastasis. This article reviews the current knowledge on the biological role of annexin A2 and its binding proteins in solid malignancies including ovarian cancer.

Citing Articles

Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas.

Christofidis K, Pergaris A, Fioretzaki R, Charalampakis N, Kapetanakis E, Kavantzas N Cancers (Basel). 2024; 16(22).

PMID: 39594718 PMC: 11592865. DOI: 10.3390/cancers16223764.

Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma.

Sharma V, Singh S, Bandyopadhyay S, Sikka K, Kakkar A, Hariprasad G Biochem Biophys Rep. 2024; 40:101842.

PMID: 39483176 PMC: 11525462. DOI: 10.1016/j.bbrep.2024.101842.

Annexin A2: A Double-Edged Sword in Pathogen Infection.

Wang T, Zhao D, Zhang Y, Yu D, Liu G, Zhang K Pathogens. 2024; 13(7).

PMID: 39057791 PMC: 11279864. DOI: 10.3390/pathogens13070564.

Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma.

Chaudhary S, Siddiqui J, Appadurai M, Maurya S, Murakonda S, Blowers E Exp Mol Med. 2024; 56(6):1450-1460.

PMID: 38825648 PMC: 11263355. DOI: 10.1038/s12276-024-01255-6.

Diagnosis of the Initial Stage of Hepatocellular Carcinoma: A Review.

Sharma K, Mohsin M, Mittal P, Ali Z, Fatma N, Upadhyay P Curr Pharm Des. 2024; 30(22):1708-1724.

PMID: 38797901 DOI: 10.2174/0113816128298875240321073907.

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