Natural Killer Cell Receptor-expressing Innate Lymphocytes: More Than Just NK Cells

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 Sep 10

PMID 21904914

Citations 8

Authors

Arthur Mortha

Andreas Diefenbach

Affiliations

Soon will be listed here.

Abstract

Recently, additional subsets that extend the family of innate lymphocytes have been discovered. Among these newly identified innate lymphoid cells is a subset sharing phenotypic characteristics of natural killer cells and lymphoid tissue inducer cells. These cells co-express the transcription factor RORγt and activating NK cell receptors (NKR), but their lineage and functional qualities remain poorly defined. Here, we discuss recent proposals to place these NKR(+)RORγt(+) innate lymphocytes on hematopoietic lineage maps. An overview of the transcriptional circuitry determining fate decisions of innate lymphocytes and a summary of current concepts concerning plasticity and stability of innate lymphocyte effector fates are provided. We will conclude by discussing the function of RORγt-expressing innate lymphocytes during inflammatory bowel diseases and in the immune response to tumors.

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