Bivariate and Multivariate NeuroXidence: A Robust and Reliable Method to Detect Modulations of Spike-Spike Synchronization Across Experimental Conditions

Overview

Journal Front Neuroinform

Specialty Neurology

Date 2011 Sep 8

PMID 21897816

Authors

Wei Wu

Diek W Wheeler

Gordon Pipa

Affiliations

Soon will be listed here.

Abstract

Synchronous neuronal firing has been proposed as a potential neuronal code. To determine whether synchronous firing is really involved in different forms of information processing, one needs to directly compare the amount of synchronous firing due to various factors, such as different experimental or behavioral conditions. In order to address this issue, we present an extended version of the previously published method, NeuroXidence. The improved method incorporates bi- and multivariate testing to determine whether different factors result in synchronous firing occurring above the chance level. We demonstrate through the use of simulated data sets that bi- and multivariate NeuroXidence reliably and robustly detects joint-spike-events across different factors.

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