Bladder Dysfunction in Patients with Diabetes

Overview

Journal Curr Urol Rep

Publisher Current Science

Specialty Urology

Date 2011 Sep 7

PMID 21894526

Citations 28

Authors

Christopher S Gomez

Prashanth Kanagarajah

Angelo E Gousse

Affiliations

Soon will be listed here.

Abstract

With diabetes mellitus (DM) reaching epidemic proportions, the identification of voiding dysfunction as a common and burdensome complication of this disease is critical. Research into diabetic voiding dysfunction significantly lags behind other complications of DM, such as retinopathy and nephropathy. Recent studies have revealed that DM predisposes patients to a wide range of lower urinary tract dysfunction, from the classic diabetic cystopathy of incomplete emptying to urgency incontinence. In this review, we discuss the current concepts of diabetic voiding dysfunction with a critical analysis of the available evidence.

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References

Hill S, Fayyad A, Jones G . Diabetes mellitus and female lower urinary tract symptoms: a review. Neurourol Urodyn. 2007; 27(5):362-7. DOI: 10.1002/nau.20533. View

Apfel S . Neurotrophic factors and diabetic peripheral neuropathy. Eur Neurol. 1999; 41 Suppl 1:27-34. DOI: 10.1159/000052077. View

Daniels D, Powell C, Braasch M, Kreder K . Sacral neuromodulation in diabetic patients: success and complications in the treatment of voiding dysfunction. Neurourol Urodyn. 2009; 29(4):578-81. DOI: 10.1002/nau.20791. View

Saito M, Kinoshita Y, Satoh I, Shinbori C, Suzuki H, Yamada M . Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. Eur Urol. 2006; 51(2):479-87. DOI: 10.1016/j.eururo.2006.06.024. View

Sasaki K, Chancellor M, Goins W, Phelan M, Glorioso J, de Groat W . Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Diabetes. 2004; 53(10):2723-30. DOI: 10.2337/diabetes.53.10.2723. View

Saito M, Okada S, Kazuyama E, Satoh I, Kinoshita Y, Satoh K . Pharmacological properties, functional alterations and gene expression of muscarinic receptors in young and old type 2 Goto-Kakizaki diabetic rat bladders. J Urol. 2008; 180(6):2701-5. DOI: 10.1016/j.juro.2008.08.002. View

Burke J, Jacobson D, McGree M, Roberts R, Girman C, Lieber M . Diabetes and benign prostatic hyperplasia progression in Olmsted County, Minnesota. Urology. 2006; 67(1):22-5. DOI: 10.1016/j.urology.2005.08.010. View

Yamaguchi C, Sakakibara R, Uchiyama T, Yamamoto T, Ito T, Liu Z . Overactive bladder in diabetes: a peripheral or central mechanism?. Neurourol Urodyn. 2007; 26(6):807-13. DOI: 10.1002/nau.20404. View

Mordes J, Desemone J, Rossini A . The BB rat. Diabetes Metab Rev. 1987; 3(3):725-50. DOI: 10.1002/dmr.5610030307. View

10.

Shinohara M, Masuyama T, Shoda T, Takahashi T, Katsuda Y, Komeda K . A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Int J Exp Diabetes Res. 2001; 1(2):89-100. PMC: 2477755. DOI: 10.1155/edr.2000.89. View

11.

Ustuner M, Kabay S, Ozden H, Guven G, Yucel M, Olgun E . The protective effects of vitamin E on urinary bladder apoptosis and oxidative stress in streptozotocin-induced diabetic rats. Urology. 2009; 75(4):902-6. DOI: 10.1016/j.urology.2009.06.003. View

12.

Chen S, Jackson S, Boyko E . Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol. 2009; 182(6 Suppl):S51-6. DOI: 10.1016/j.juro.2009.07.090. View

13.

Lifford K, Curhan G, Hu F, Barbieri R, Grodstein F . Type 2 diabetes mellitus and risk of developing urinary incontinence. J Am Geriatr Soc. 2005; 53(11):1851-7. DOI: 10.1111/j.1532-5415.2005.53565.x. View

14.

Lee W, Wu H, Tai T, Liu S, Chen J, Yu H . Effects of diabetes on female voiding behavior. J Urol. 2004; 172(3):989-92. DOI: 10.1097/01.ju.0000136255.83054.0c. View

15.

Van Den Eeden S, Sarma A, Rutledge B, Cleary P, Kusek J, Nyberg L . Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes Care. 2009; 32(4):664-70. PMC: 2660483. DOI: 10.2337/dc07-2375. View

16.

Fayyad A, Hill S, Jones G . Urine production and bladder diary measurements in women with type 2 diabetes mellitus and their relation to lower urinary tract symptoms and voiding dysfunction. Neurourol Urodyn. 2009; 29(3):354-8. DOI: 10.1002/nau.20778. View

17.

Lee W, Wu H, Tai T, Yu H, Chiang P . Investigation of urodynamic characteristics and bladder sensory function in the early stages of diabetic bladder dysfunction in women with type 2 diabetes. J Urol. 2008; 181(1):198-203. DOI: 10.1016/j.juro.2008.09.021. View

18.

Yoshimura N, Chancellor M, Andersson K, Christ G . Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int. 2005; 95(6):733-8. DOI: 10.1111/j.1464-410X.2005.05392.x. View

19.

Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell C . Temporal differences in bladder dysfunction caused by diabetes, diuresis, and treated diabetes in mice. Am J Physiol Regul Integr Comp Physiol. 2006; 290(6):R1728-35. DOI: 10.1152/ajpregu.00654.2005. View

20.

Kitami K . [Vesicourethral dysfunction of diabetic patients]. Nihon Hinyokika Gakkai Zasshi. 1991; 82(7):1074-83. DOI: 10.5980/jpnjurol1989.82.1074. View