Reduction in Serum High Mobility Group Box-1 Level by Polymyxin B-immobilized Fiber Column in Patients with Idiopathic Pulmonary Fibrosis with Acute Exacerbation

Overview

Journal Blood Purif

Specialty Hematology

Date 2011 Sep 7

PMID 21893977

Citations 31

Authors

Shinji Abe

Hiroki Hayashi

Yoshitsugu Seo

Kuniko Matsuda

Koichiro Kamio

Yoshinobu Saito

Jiro Usuki

Arata Azuma

Shoji Kudo

Akihiko Gemma

Affiliations

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Abstract

Background/aim: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE.

Materials And Methods: Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX.

Results: PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column.

Conclusion: PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE.

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