Use of Alkyl 2,4,6-triisopropylbenzoates in the Asymmetric Homologation of Challenging Boronic Esters

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2011 Sep 6

PMID 21892499

Citations 20

Authors

Robin Larouche-Gauthier

Catherine J Fletcher

Irantzu Couto

Varinder K Aggarwal

Affiliations

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Abstract

(-)-Sparteine induced lithiation of primary 2,4,6-triisopropylbenzoates and subsequent homologation of boronic esters is reported. A comparative study with lithiated N,N-diisopropylcarbamates has demonstrated the superiority of the hindered benzoate.

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