Overview of Basic Mechanisms of Cardiac Arrhythmia

Overview

Journal Card Electrophysiol Clin

Specialties Cardiology & Vascular Diseases
Physiology

Date 2011 Sep 6

PMID 21892379

Citations 138

Authors

Charles Antzelevitch

Alexander Burashnikov

Affiliations

Soon will be listed here.

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References

Antzelevitch C, Shimizu W . Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol. 2002; 17(1):43-51. DOI: 10.1097/00001573-200201000-00007. View

Nof E, Burashnikov A, Antzelevitch C . Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy. Heart Rhythm. 2010; 7(2):251-7. PMC: 2826201. DOI: 10.1016/j.hrthm.2009.10.017. View

Garfinkel A, Kim Y, Voroshilovsky O, Qu Z, Kil J, Lee M . Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci U S A. 2000; 97(11):6061-6. PMC: 18558. DOI: 10.1073/pnas.090492697. View

LAZZARA R, El-Sherif N, Scherlag B . Electrophysiological properties of canine Purkinje cells in one-day-old myocardial infarction. Circ Res. 1973; 33(6):722-34. DOI: 10.1161/01.res.33.6.722. View

Roden D . Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med. 2005; 259(1):59-69. DOI: 10.1111/j.1365-2796.2005.01589.x. View

Sicouri S, Antzelevitch C . A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res. 1991; 68(6):1729-41. DOI: 10.1161/01.res.68.6.1729. View

Shimizu W, Antzelevitch C . Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome. Circulation. 2000; 102(6):706-12. DOI: 10.1161/01.cir.102.6.706. View

Patterson E, Po S, Scherlag B, Lazzara R . Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm. 2005; 2(6):624-31. DOI: 10.1016/j.hrthm.2005.02.012. View

WASSERBURGER R, ALT W . The normal RS-T segment elevation variant. Am J Cardiol. 1961; 8:184-92. DOI: 10.1016/0002-9149(61)90204-1. View

10.

Huser J, Blatter L, Lipsius S . Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol. 2000; 524 Pt 2:415-22. PMC: 2269880. DOI: 10.1111/j.1469-7793.2000.00415.x. View

11.

Aiba T, Tomaselli G . Electrical remodeling in the failing heart. Curr Opin Cardiol. 2009; 25(1):29-36. PMC: 2855498. DOI: 10.1097/HCO.0b013e328333d3d6. View

12.

Burashnikov A, Antzelevitch C . Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity. Circulation. 2003; 107(18):2355-60. DOI: 10.1161/01.CIR.0000065578.00869.7C. View

13.

MEHTA M, Jain A . Early repolarization on scalar electrocardiogram. Am J Med Sci. 1995; 309(6):305-11. DOI: 10.1097/00000441-199506000-00001. View

14.

Allessie M, Bonke F, Schopman F . Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ Res. 1977; 41(1):9-18. DOI: 10.1161/01.res.41.1.9. View

15.

Wit A, Cranefield P, Hoffman B . Slow conduction and reentry in the ventricular conducting system. II. Single and sustained circus movement in networks of canine and bovine Purkinje fibers. Circ Res. 1972; 30(1):11-22. DOI: 10.1161/01.res.30.1.11. View

16.

Anyukhovsky E, Sosunov E, Rosen M . Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium. In vitro and in vivo correlations. Circulation. 1996; 94(8):1981-8. DOI: 10.1161/01.cir.94.8.1981. View

17.

Bjerregaard P, Gussak I, Kotar S, Gessler J, Janosik D . Recurrent syncope in a patient with prominent J wave. Am Heart J. 1994; 127(5):1426-30. DOI: 10.1016/0002-8703(94)90070-1. View

18.

Schulze-Bahr E, Neu A, Friederich P, Kaupp U, Breithardt G, Pongs O . Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest. 2003; 111(10):1537-45. PMC: 155041. DOI: 10.1172/JCI16387. View

19.

Morita H, Morita S, Nagase S, Banba K, Nishii N, Tani Y . Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome. J Am Coll Cardiol. 2003; 42(9):1624-31. DOI: 10.1016/j.jacc.2003.06.004. View

20.

Sipido K, Volders P, de Groot S, Verdonck F, Van de Werf F, Wellens H . Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis. Circulation. 2000; 102(17):2137-44. DOI: 10.1161/01.cir.102.17.2137. View