Advances and Developments in the Use of Human Mesenchymal Stem Cells - a Few Considerations

Overview

Journal Open Orthop J

Publisher Bentham Open

Specialty Orthopedics

Date 2011 Sep 6

PMID 21892368

Citations 3

Authors

Lucinda Kennard

Gopiga Thanabalasundaram

Hiteshkumar D Tailor

Wasim S Khan

Affiliations

Soon will be listed here.

Abstract

One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.

Citing Articles

Tendon regeneration and repair with stem cells.

Maclean S, Khan W, Malik A, Snow M, Anand S Stem Cells Int. 2014; 2012:316281.

PMID: 25098364 PMC: 3205775. DOI: 10.1155/2012/316281.

An osteoconductive, osteoinductive, and osteogenic tissue-engineered product for trauma and orthopaedic surgery: how far are we?.

Khan W, Rayan F, Dhinsa B, Marsh D Stem Cells Int. 2014; 2012:236231.

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The potential of stem cells in the treatment of skeletal muscle injury and disease.

Maclean S, Khan W, Malik A, Anand S, Snow M Stem Cells Int. 2012; 2012:282348.

PMID: 22220178 PMC: 3246792. DOI: 10.1155/2012/282348.

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