Review: Mitochondrial Defects in Breast Cancer

Overview

Journal Clin Med Oncol

Publisher Libertas Academica

Specialty Oncology

Date 2011 Sep 6

PMID 21892280

Citations 5

Authors

Josefa Salgado

Beatriz Honorato

Jesus Garcia-Foncillas

Affiliations

Soon will be listed here.

Abstract

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Mitochondrial DNA has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. Breast cancer is the most frequent cancer type among women in the world and, although exhaustive research has been done on nuclear DNA changes, several studies describe a variety of mitochondrial DNA alterations present in breast cancer. In this review article, we to provide a summary of the mitochondrial genomic alterations reported in breast cancer and their functional consequences.

Citing Articles

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Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity.

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Immortalization of Different Breast Epithelial Cell Types Results in Distinct Mitochondrial Mutagenesis.

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The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.

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The saga of the many studies wrongly associating mitochondrial DNA with breast cancer.

Salas A, Garcia-Magarinos M, Logan I, Bandelt H BMC Cancer. 2014; 14:659.

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