Expert Opinion: Responsive Polymer Nanoparticles in Cancer Therapy

Overview

Journal Eur J Pharm Biopharm

Specialty Pharmacology

Date 2011 Sep 6

PMID 21888972

Citations 63

Authors

William B Liechty

Nicholas A Peppas

Affiliations

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Abstract

Polymeric nanoparticles are emerging as an attractive treatment options for cancer due to their favorable size distribution, drug carrying capacity, and tunable properties. In particular, intelligent nanoparticles that respond to biological cues are of interest because of their ability to provide controlled release at a specific site. Tumor sites display abnormal pH profiles and pathophysiology that can be exploited to provide localized release. In this expert opinion, we discuss passive and active targeting of nanoparticles and several classes of pH-responsive nanoparticles.

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