Alpha 2.0
Login Register
» Articles » PMID: 21888792

Geographic Distribution of Endemic Fungal Infections Among Older Persons, United States

Overview
Journal Emerg Infect Dis
Specialty Infectious Diseases
Date 2011 Sep 6
PMID 21888792
Citations 72
Authors
John W Baddley
Kevin L Winthrop
Nivedita M Patkar
Elizabeth Delzell
Timothy Beukelman
Fenglong Xie
Lang Chen
Jeffrey R Curtis
Affiliations
Soon will be listed here.
Abstract

To investigate the epidemiology and geographic distribution of histoplasmosis, coccidioidomycosis, and blastomycosis in older persons in the United States, we evaluated a random 5% sample of national Medicare data from 1999 through 2008. We calculated national, regional, and state-based incidence rates and determined 90-day postdiagnosis mortality rates. We identified 776 cases (357 histoplasmosis, 345 coccidioidomycosis, 74 blastomycosis). Patient mean age was 75.7 years; 55% were male. Histoplasmosis and blastomycosis incidence was highest in the Midwest (6.1 and 1.0 cases/100,000 person-years, respectively); coccidioidomycosis incidence rate was highest in the West (15.2). On the basis of available data, for 86 (11.1%) cases, there was no patient exposure to a traditional disease-endemic area. Knowledge of areas where endemic mycosis incidence is increased may affect diagnostic or prevention measures for older adults at risk.

Citing Articles

Disseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.

Sleightholm R, Hodson D, So I, Avula H, Batra J J Med Case Rep. 2024; 18(1):540.

PMID: 39511652 PMC: 11545083. DOI: 10.1186/s13256-024-04856-x.

Management and outcomes of histoplasmosis in youth with inflammatory bowel disease in an endemic area.

Wright J, Ardura M, Dotson J, Boyle B, Maltz R, Michel H J Pediatr Gastroenterol Nutr. 2024; 79(6):1153-1163.

PMID: 39329236 PMC: 11615130. DOI: 10.1002/jpn3.12381.

Parasitic and Fungal Triggers of Cytokine Storm Syndrome.

Sterba G, Sterba Y Adv Exp Med Biol. 2024; 1448:293-305.

PMID: 39117823 DOI: 10.1007/978-3-031-59815-9_21.

Genotypic diversity, virulence, and molecular genetic tools in .

Sepulveda V, Goldman W, Matute D Microbiol Mol Biol Rev. 2024; 88(2):e0007623.

PMID: 38819148 PMC: 11332355. DOI: 10.1128/mmbr.00076-23.

Development and validation of a preliminary multivariable diagnostic model for identifying unusual infections in hospitalized patients.

Tekin A, Joghataee M, Rovati L, Truong H, Castillo-Zambrano C, Kushagra K Biomol Biomed. 2024; 24(5):1387-1399.

PMID: 38643478 PMC: 11379024. DOI: 10.17305/bb.2024.10447.

References
1.
Baumgardner D, Knavel E, Steber D, Swain G . Geographic distribution of human blastomycosis cases in Milwaukee, Wisconsin, USA: association with urban watersheds. Mycopathologia. 2006; 161(5):275-82. DOI: 10.1007/s11046-006-0018-9. View
2.
Curtis J, Martin C, Saag K, Patkar N, Kramer J, Shatin D . Confirmation of administrative claims-identified opportunistic infections and other serious potential adverse events associated with tumor necrosis factor alpha antagonists and disease-modifying antirheumatic drugs. Arthritis Rheum. 2007; 57(2):343-6. DOI: 10.1002/art.22544. View
3.
Winthrop K, Chiller T . Preventing and treating biologic-associated opportunistic infections. Nat Rev Rheumatol. 2009; 5(7):405-10. DOI: 10.1038/nrrheum.2009.105. View
4.
Blair J, Mayer A, Currier J, Files J, Wu Q . Coccidioidomycosis in elderly persons. Clin Infect Dis. 2008; 47(12):1513-8. DOI: 10.1086/593192. View
5.
Schneeweiss S, Robicsek A, Scranton R, Zuckerman D, Solomon D . Veteran's affairs hospital discharge databases coded serious bacterial infections accurately. J Clin Epidemiol. 2007; 60(4):397-409. DOI: 10.1016/j.jclinepi.2006.07.011. View