Cylindroma Transforming into Basal Cell Carcinoma in a Patient with Brooke-Spiegler Syndrome

Overview

Journal J Dermatol Case Rep

Specialty Dermatology

Date 2011 Sep 3

PMID 21886698

Citations 6

Authors

Justyna Sicinska

Adriana Rakowska

Joanna Czuwara-Ladykowska

Andrzej Mroz

Marcin Lipinski

Anna Nasierowska-Guttmejer

Jolanta Sikorska

Katarzyna Sklinda

Monika Slowinska

Elzbieta Kowalska-Oledzka

Irena Walecka

Jerzy Walecki

Lidia Rudnicka

Affiliations

Soon will be listed here.

Abstract

Background: Brooke-Spiegler syndrome is a rare condition with a predisposition to develop cutaneous adnexal neoplasms, especially cylindromas, trichoepitheliomas and spiradenomas. Malignant transformation of cylindromas is rare. In such cases usually cylindrocarcinomas develop within these lesions. We present an unusual case of basal cell carcinoma developing within a preexisting cylindroma.

Main Observations: 58-year-old woman with a 30-year history of multiple dermal cylindromas extensively involving her scalp was referred for dermatological treatment. The patient reported that one of the long-lasting lesions, 5.5 cm in size, ulcerated within the foregoing few weeks. Histopathology confirmed cylindromas and basal cell carcinoma within the ulcerating tumor. Surgical excision of largest cylindroma tumors led to cosmetic and functional improvement. Magnetic resonance and computed tomography showed tumor infiltration into the skull lamina externa. Metastases were excluded by chest radiography and abdominal ultrasound examination.

Conclusion: Patients with Brooke-Spiegler syndrome should be followed-up for malignant transformation of skin tumors to prevent deep penetration and possible metastases.

Citing Articles

Minimally Invasive Plasma Device Management of Multiple Benign Skin Cancers Associated with Rare Genodermatoses-Case Series and Review of the Therapeutic Methods.

Platkowska A, Slowinska M, Zalewska J, Swacha Z, Szumera-Cieckiewicz A, Wagrodzki M J Clin Med. 2024; 13(15).

PMID: 39124644 PMC: 11312861. DOI: 10.3390/jcm13154377.

Nonmelanoma Skin Cancer with Skull Infiltration and Cranial Involvement.

Wollina U, Kittner T, Nowak A Open Access Maced J Med Sci. 2019; 7(18):3030-3033.

PMID: 31850116 PMC: 6910817. DOI: 10.3889/oamjms.2019.416.

[Cylindromas-rare but striking].

Loser C, Rutten A, Dippel E Hautarzt. 2019; 70(9):677-683.

PMID: 31428801 DOI: 10.1007/s00105-019-4458-9.

Brooke-Spiegler Syndrome.

Mohiuddin W, Laun J, Cruse W Eplasty. 2018; 18:ic14.

PMID: 30093932 PMC: 6062842.

Basaloid Squamous Cell Carcinoma of Scalp From A Pre-Existing Cylindroma Metastasising To Brain: A Rare Case Report.

Diwakar I, Srinivas T, Kolakebail J, Shetty J, Kukreja P J Clin Diagn Res. 2016; 10(5):ED16-7.

PMID: 27437239 PMC: 4948415. DOI: 10.7860/JCDR/2016/15691.7836.

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