Improvement in Sleep Apnoea Associated with Switch from Simvastatin to Pravastatin

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2011 Sep 3

PMID 21886657

Citations 4

Authors

Stephanie Cham

Komaldeep Gill

Sabrina Koperski

Beatrice Alexandra Golomb

Affiliations

Soon will be listed here.

Abstract

Sleep problems have been reported as an adverse effect of statins. In a randomised trial, simvastatin at 20 mg produced significantly worse sleep quality than either placebo or pravastatin 40 mg. A possible relation to sleep apnoea was hypothesised. Here, the case of a 67-year-old man who experienced sleep apnoea on simvastatin 20 mg is presented. Objective nightly testing showed a prompt, marked, sustained and statistically significant improvement in the obstructive apnoea index when the patient switched to pravastatin 20 mg.

Citing Articles

Statin Use in Relation to COVID-19 and Other Respiratory Infections: Muscle and Other Considerations.

Golomb B, Han J, Langsjoen P, Dinkeloo E, Zemljic-Harpf A J Clin Med. 2023; 12(14).

PMID: 37510774 PMC: 10380486. DOI: 10.3390/jcm12144659.

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series.

Cham S, Koslik H, Golomb B Drug Saf Case Rep. 2016; 3(1):1.

PMID: 27747681 PMC: 5005588. DOI: 10.1007/s40800-015-0024-2.

Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial.

Golomb B, Dimsdale J, Koslik H, Evans M, Lu X, Rossi S PLoS One. 2015; 10(7):e0124451.

PMID: 26132393 PMC: 4488854. DOI: 10.1371/journal.pone.0124451.

Impact of medications on cognitive function in obstructive sleep apnea syndrome.

Lal C, Siddiqi N, Kumbhare S, Strange C Sleep Breath. 2015; 19(3):939-45.

PMID: 25566945 DOI: 10.1007/s11325-014-1105-7.

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