Association Analysis of the Adenosine A1 Receptor Gene Polymorphisms in Patients with Methamphetamine Dependence/psychosis

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2011 Sep 3

PMID 21886579

Citations 4

Authors

Hideaki Kobayashi

Hiroshi Ujike

Nakao Iwata

Toshiya Inada

Mitsuhiko Yamada

Yoshimoto Sekine

Naohisa Uchimura

Masaomi Iyo

Norio Ozaki

Masanari Itokawa

Ichiro Sora

Affiliations

Soon will be listed here.

Abstract

Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors in METH abusers. We therefore hypothesized that variations in the A1 adenosine receptor (ADORA1) gene modify genetic susceptibility to METH dependence/psychosis. In this study, we identified 7 single nucleotide polymorphisms (SNPs) in exons and exon-intron boundaries of the ADORA1 gene in a Japanese population. A total of 171 patients and 229 controls were used for an association analysis between these SNPs and METH dependence/psychosis. No significant differences were observed in either the genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. In the clinical feature analyses, no significant associations were observed among latency of psychosis, prognosis of psychosis, and spontaneous relapse. These results suggest that the ADORA1 gene variants may make little or no contribution to vulnerability to METH dependence/psychosis.

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References

Turgeon S, Pollack A, Schusheim L, Fink J . Effects of selective adenosine A1 and A2a agonists on amphetamine-induced locomotion and c-Fos in striatum and nucleus accumbens. Brain Res. 1996; 707(1):75-80. DOI: 10.1016/0006-8993(95)01223-0. View

Munzar P, Justinova Z, Kutkat S, Ferre S, Goldberg S . Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology (Berl). 2002; 161(4):348-55. DOI: 10.1007/s00213-002-1075-5. View

Alsene K, Deckert J, Sand P, de Wit H . Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology. 2003; 28(9):1694-702. DOI: 10.1038/sj.npp.1300232. View

Wilson J, Kalasinsky K, Levey A, Bergeron C, Reiber G, Anthony R . Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nat Med. 1996; 2(6):699-703. DOI: 10.1038/nm0696-699. View

Di Chiara G, Imperato A . Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A. 1988; 85(14):5274-8. PMC: 281732. DOI: 10.1073/pnas.85.14.5274. View

Delle Donne K, Sonsalla P . Protection against methamphetamine-induced neurotoxicity to neostriatal dopaminergic neurons by adenosine receptor activation. J Pharmacol Exp Ther. 1994; 271(3):1320-6. View

Poleszak E, Malec D . Effects of adenosine receptor agonists and antagonists in amphetamine-induced conditioned place preference test in rats. Pol J Pharmacol. 2003; 55(3):319-26. View

Giros B, Jaber M, Jones S, Wightman R, Caron M . Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 1996; 379(6566):606-12. DOI: 10.1038/379606a0. View

Matsumoto T, Kamijo A, Miyakawa T, Endo K, Yabana T, Kishimoto H . Methamphetamine in Japan: the consequences of methamphetamine abuse as a function of route of administration. Addiction. 2002; 97(7):809-17. DOI: 10.1046/j.1360-0443.2002.00143.x. View

10.

Volkow N, Chang L, Wang G, Fowler J, Franceschi D, Sedler M . Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am J Psychiatry. 2001; 158(3):377-82. DOI: 10.1176/appi.ajp.158.3.377. View

11.

Deckert J, Nothen M, Franke P, Delmo C, Fritze J, Knapp M . Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease. Mol Psychiatry. 1998; 3(1):81-5. DOI: 10.1038/sj.mp.4000345. View

12.

Ferre S, Fredholm B, Morelli M, Popoli P, Fuxe K . Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 1997; 20(10):482-7. DOI: 10.1016/s0166-2236(97)01096-5. View

13.

Justinova Z, Ferre S, Segal P, Antoniou K, Solinas M, Pappas L . Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats. J Pharmacol Exp Ther. 2003; 307(3):977-86. DOI: 10.1124/jpet.103.056762. View

14.

ONeill C, Nolan B, Macari A, OBoyle K, OConnor J . Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors. Eur J Neurosci. 2007; 26(12):3421-8. DOI: 10.1111/j.1460-9568.2007.05953.x. View

15.

Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y . Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J. 2003; 3(4):242-7. DOI: 10.1038/sj.tpj.6500189. View

16.

Poleszak E, MALEC D . Influence of adenosine receptor agonists and antagonists on amphetamine-induced stereotypy in rats. Pol J Pharmacol. 2001; 52(6):423-9. View

17.

Ferre S, Fuxe K, von Euler G, Johansson B, Fredholm B . Adenosine-dopamine interactions in the brain. Neuroscience. 1992; 51(3):501-12. DOI: 10.1016/0306-4522(92)90291-9. View

18.

Deckert J, Nothen M, Albus M, Franzek E, Rietschel M, Ren H . Adenosine A1 receptor and bipolar affective disorder: systematic screening of the gene and association studies. Am J Med Genet. 1998; 81(1):18-23. DOI: 10.1002/(sici)1096-8628(19980207)81:1<18::aid-ajmg4>3.0.co;2-j. View

19.

Ren H, Stiles G . Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance. Mol Pharmacol. 1995; 48(6):975-80. View

20.

Hohoff C, McDonald J, Baune B, Cook E, Deckert J, de Wit H . Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. Am J Med Genet B Neuropsychiatr Genet. 2005; 139B(1):42-4. DOI: 10.1002/ajmg.b.30228. View