Converting Human Skin Cells to Neurons: a New Tool to Study and Treat Brain Disorders?

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2011 Sep 3

PMID 21885012

Citations 7

Authors

Kwang-Soo Kim

Affiliations

Soon will be listed here.

Abstract

Recent publications in Cell Stem Cell (Son et al., 2011; Ambasudhan et al., 2011), PNAS (Pfisterer et al., 2011), and Nature (Caiazzo et al., 2011; Pang et al., 2011; Yoo et al., 2011) report that functional neurons can be directly generated from human fibroblast cells without going through the pluripotent state.

Citing Articles

Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects.

Sonntag K, Song B, Lee N, Jung J, Cha Y, Leblanc P Prog Neurobiol. 2018; 168:1-20.

PMID: 29653250 PMC: 6077089. DOI: 10.1016/j.pneurobio.2018.04.005.

Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus.

Avaliani N, Pfisterer U, Heuer A, Parmar M, Kokaia M, Andersson M Stem Cells Int. 2018; 2017:5718608.

PMID: 29317869 PMC: 5727793. DOI: 10.1155/2017/5718608.

Reprogramming cell fates by small molecules.

Ma X, Kong L, Zhu S Protein Cell. 2017; 8(5):328-348.

PMID: 28213718 PMC: 5413596. DOI: 10.1007/s13238-016-0362-6.

Generation of functional human serotonergic neurons from fibroblasts.

Vadodaria K, Mertens J, Paquola A, Bardy C, Li X, Jappelli R Mol Psychiatry. 2015; 21(1):49-61.

PMID: 26503761 DOI: 10.1038/mp.2015.161.

Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells.

Hong S, Chung S, Leung K, Hwang I, Moon J, Kim K Stem Cells Dev. 2013; 23(5):477-87.

PMID: 24172139 PMC: 3928687. DOI: 10.1089/scd.2013.0406.