B7-H6/NKp30 Interaction: a Mechanism of Alerting NK Cells Against Tumors

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 Aug 31

PMID 21877119

Citations 54

Authors

Tomonori Kaifu

Bertrand Escaliere

Louis N Gastinel

Eric Vivier

Myriam Baratin

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.

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