Swimming Exercise in the Acute or Late Phase After Sciatic Nerve Crush Accelerates Nerve Regeneration

Overview

Journal Neural Plast

Specialty Neurology

Date 2011 Aug 31

PMID 21876821

Citations 20

Authors

Rosana Macher Teodori

Joice Betini

Larissa Salgado de Oliveira

Luciane Lobato Sobral

Sibele Yoko Mattozo Takeda

Maria Imaculada de Lima Montebelo

Affiliations

Soon will be listed here.

Abstract

There is no consensus about the best time to start exercise after peripheral nerve injury. We evaluated the morphological and functional characteristics of the sciatic nerves of rats that began to swim immediately after crush nerve injury (CS1), those that began to swim 14 days after injury (CS14), injured rats not submitted to swimming (C), and uninjured rats submitted to swimming (S). After 30 days the number of axons in CS1 and CS14 was lower than in C (P < 0.01). The diameter of axons and nerve fibers was larger in CS1 (P < 0.01) and CS14 (P < 0.05) than in C, and myelin sheath thickness was lower in all crushed groups (P < 0.05). There was no functional difference between CS1 and CS14 (P > 0.05). Swimming exercise applied during the acute or late phase of nerve injury accelerated nerve regeneration and synaptic elimination after axonotmesis, suggesting that exercise may be initiated immediately after injury.

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References

Aas V, Torbla S, Andersen M, Jensen J, Rustan A . Electrical stimulation improves insulin responses in a human skeletal muscle cell model of hyperglycemia. Ann N Y Acad Sci. 2002; 967:506-15. DOI: 10.1111/j.1749-6632.2002.tb04309.x. View

Oliveira L, Sobral L, Takeda S, Betini J, Guirro R, Somazz M . [Electrical stimulation and swimming in the acute phase of axonotmesis: their influence on nerve regeneration and functional recovery]. Rev Neurol. 2008; 47(1):11-5. View

Sanes J, Lichtman J . Development of the vertebrate neuromuscular junction. Annu Rev Neurosci. 1999; 22:389-442. DOI: 10.1146/annurev.neuro.22.1.389. View

Tam S, Archibald V, Jassar B, Tyreman N, Gordon T . Increased neuromuscular activity reduces sprouting in partially denervated muscles. J Neurosci. 2001; 21(2):654-67. PMC: 6763816. View

Torch S, Usson Y, Saxod R . Automated morphometric study of human peripheral nerves by image analysis. Pathol Res Pract. 1989; 185(5):567-71. DOI: 10.1016/S0344-0338(89)80195-5. View

Herbison G, Jaweed M, Ditunno J . Effect of swimming on reinnervation of rat skeletal muscle. J Neurol Neurosurg Psychiatry. 1974; 37(11):1247-51. PMC: 494889. DOI: 10.1136/jnnp.37.11.1247. View

Pette D, Staron R . Transitions of muscle fiber phenotypic profiles. Histochem Cell Biol. 2001; 115(5):359-72. DOI: 10.1007/s004180100268. View

Lundborg G . Nerve regeneration and repair. A review. Acta Orthop Scand. 1987; 58(2):145-69. DOI: 10.3109/17453678709146461. View

Dash H, Kononov A, Prayson R, Petras S, Browne E . Evaluation of nerve recovery from minimal-duration crush injury. Ann Plast Surg. 1996; 37(5):526-31. DOI: 10.1097/00000637-199611000-00012. View

10.

de Medinaceli L, Freed W, Wyatt R . An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol. 1982; 77(3):634-43. DOI: 10.1016/0014-4886(82)90234-5. View

11.

Lundborg G . Brain plasticity and hand surgery: an overview. J Hand Surg Br. 2000; 25(3):242-52. DOI: 10.1054/jhsb.1999.0339. View

12.

Lee S, Wolfe S . Peripheral nerve injury and repair. J Am Acad Orthop Surg. 2000; 8(4):243-52. DOI: 10.5435/00124635-200007000-00005. View

13.

Voltarelli F, Gobatto C, de Mello M . Determination of anaerobic threshold in rats using the lactate minimum test. Braz J Med Biol Res. 2002; 35(11):1389-94. DOI: 10.1590/s0100-879x2002001100018. View

14.

Sarikcioglu L, Oguz N . Exercise training and axonal regeneration after sciatic nerve injury. Int J Neurosci. 2001; 109(3-4):173-7. DOI: 10.3109/00207450108986533. View

15.

Kristeva R, Cheyne D, Deecke L . Neuromagnetic fields accompanying unilateral and bilateral voluntary movements: topography and analysis of cortical sources. Electroencephalogr Clin Neurophysiol. 1991; 81(4):284-98. DOI: 10.1016/0168-5597(91)90015-p. View

16.

Fawcett J, Keynes R . Peripheral nerve regeneration. Annu Rev Neurosci. 1990; 13:43-60. DOI: 10.1146/annurev.ne.13.030190.000355. View

17.

Byun Y, Lee M, Kim S, Kim H, Chang H, Lee T . Treadmill running promotes functional recovery and decreases brain-derived neurotrophic factor mRNA expression following sciatic crushed nerve injury in rats. J Sports Med Phys Fitness. 2005; 45(2):222-8. View

18.

van Meeteren N, Brakkee J, Hamers F, Helders P, Gispen W . Exercise training improves functional recovery and motor nerve conduction velocity after sciatic nerve crush lesion in the rat. Arch Phys Med Rehabil. 1997; 78(1):70-7. DOI: 10.1016/s0003-9993(97)90013-7. View

19.

Lundborg G . Richard P. Bunge memorial lecture. Nerve injury and repair--a challenge to the plastic brain. J Peripher Nerv Syst. 2003; 8(4):209-26. DOI: 10.1111/j.1085-9489.2003.03027.x. View

20.

Merzenich M, Kaas J, Wall J, Sur M, Nelson R, Felleman D . Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys. Neuroscience. 1983; 10(3):639-65. DOI: 10.1016/0306-4522(83)90208-7. View