Histaminergic Mechanisms for Modulation of Memory Systems

Overview

Journal Neural Plast

Specialty Neurology

Date 2011 Aug 31

PMID 21876818

Citations 20

Authors

Cristiano Andre Kohler

Weber Claudio da Silva

Fernando Benetti

Juliana Sartori Bonini

Affiliations

Soon will be listed here.

Abstract

Encoding for several memory types requires neural changes and the activity of distinct regions across the brain. These areas receive broad projections originating in nuclei located in the brainstem which are capable of modulating the activity of a particular area. The histaminergic system is one of the major modulatory systems, and it regulates basic homeostatic and higher functions including arousal, circadian, and feeding rhythms, and cognition. There is now evidence that histamine can modulate learning in different types of behavioral tasks, but the exact course of modulation and its mechanisms are controversial. In the present paper we review the involvement of the histaminergic system and the effects histaminergic receptor agonists/antagonists have on the performance of tasks associated with the main memory types as well as evidence provided by studies with knockout models. Thus, we aim to summarize the possible effects histamine has on modulation of circuits involved in memory formation.

Citing Articles

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Metabotropic Acetylcholine and Glutamate Receptors Mediate PI(4,5)P Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ.

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