Lamin A, Farnesylation and Aging

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2011 Aug 30

PMID 21871450

Citations 39

Authors

Sita Reddy

Lucio Comai

Affiliations

Soon will be listed here.

Abstract

Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LMNA gene, which result in the development of at least ten distinct human disorders, collectively known as laminopathies, among which is the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). The majority of HGPS cases are associated with a single point mutation in the LMNA gene that causes the production of a permanently farnesylated mutant lamin A protein termed progerin. The mechanism by which progerin leads to premature aging and the classical HGPS disease phenotype as well as the relationship between this disorder and the onset of analogous symptoms during the lifespan of a normal individual are not well understood. Yet, recent studies have provided critical insights on the cellular processes that are affected by accumulation of progerin and have suggested that cellular alterations in the lamin A processing pathway leading to the accumulation of farnesylated prelamin A intermediates may play a role in the aging process in the general population. In this review we provide a short background on lamin A and its maturation pathway and discuss the current knowledge of how progerin or alterations in the prelamin A processing pathway are thought to influence cell function and contribute to human aging.

Citing Articles

Molecular Mechanisms for the Regulation of Nuclear Membrane Integrity.

Lee G, Byun J, Lee C, Cho Y Int J Mol Sci. 2023; 24(20).

PMID: 37895175 PMC: 10607757. DOI: 10.3390/ijms242015497.

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies.

Hartinger R, Lederer E, Schena E, Lattanzi G, Djabali K Cells. 2023; 12(10).

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Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.

Zhou Y, Yang J, Cheng Y, Feng G, Yang R, Yuan Y Cells. 2022; 11(24).

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Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.

Bai Y, Liu J, Jiang X, Li X, Zhang B, Luo X Cells. 2022; 11(23).

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Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction.

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