CD40 C/T(-1) and CTLA-4 A/G(49) SNPs Are Associated with Autoimmune Thyroid Diseases in the Chinese Population

Overview

Journal Endocrine

Specialty Endocrinology

Date 2011 Aug 26

PMID 21866398

Citations 26

Authors

Jing Yang

Qiu Qin

Ni Yan

Yuan-Feng Zhu

Cui Li

Xiang-Ju Yang

Xuan Wang

Madhu Pandey

Peng Hou

Jin-An Zhang

Affiliations

Soon will be listed here.

Abstract

This study was to investigate whether the common polymorphisms of CD40 and CTLA4 genes confer susceptibility to AITD in the Chinese population. A set of unrelated subjects including 303 GD patients, 208 HT patients, and 215 matched healthy controls were recruited. SNPs were genotyped by the method of PCR-RFLP. (1) As for CD40 C/T(-1) SNP, only a significant difference was found in allele frequencies between GD and control groups (P = 0.033). (2) On the part of CTLA-4 A/G(49) SNP, significant differences were found in genotype and allele frequencies between GD and control groups (P = 7.0 × 10(-5) and P = 0.002, respectively), and similar results were found between HT and control groups (P = 0.015 and P = 0.003, respectively). (3) The logistic regression analysis showed there was no interaction between CD40 and CTLA4 genotypes (P = 0.262). These results indicate that both CTLA-4 A/G(49) and CD40 C/T(-1) SNPs are associated with genetic susceptibility of GD, and CTLA-4 A/G(49) is also associated with HT.

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