Role of Angiogenetic Factors in Cardiac Valve Homeostasis and Disease

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2011 Aug 26

PMID 21866383

Citations 4

Authors

Daihiko Hakuno

Naritaka Kimura

Masatoyo Yoshioka

Keiichi Fukuda

Affiliations

Soon will be listed here.

Abstract

The aging of populations worldwide and the habitual consumption of food high in calories and cholesterol have led to recent increases in morbidity from calcific aortic valve disease. At the same time, rupture of the chordae tendineae cordis, which is a component of the mitral valve complex, is one of the major causes of mitral regurgitation. Surgery is the basis of treatment for these diseases, and little is known about their causes and mechanisms. A balance of angiogenetic and angioinhibitory factors is crucial for normal development and homeostasis of many organs. Although the heart is a vascular-rich organ, most of the cardiac valve complex is avascular like cartilage and tendons. Our studies have focused on the role of angiogenetic factors expressed in the cartilage and tendons in cardiac valve homeostasis. Recently, we found that chondromodulin-I, tenomodulin, and periostin play essential roles in degeneration and/or rupture of the cardiac valve complex by controlling angiogenesis and matrix metalloproteinase production. Here, we review the mechanistic insights provided by these studies and the proposed roles of angiogenetic factors in cardiac valve homeostasis and disease.

Citing Articles

Angiogenic Secretion Profile of Valvular Interstitial Cells Varies With Cellular Sex and Phenotype.

Nelson V, Patil V, Simon L, Schmidt K, McCoy C, Masters K Front Cardiovasc Med. 2021; 8:736303.

PMID: 34527715 PMC: 8435671. DOI: 10.3389/fcvm.2021.736303.

RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio.

Saddala M, Lennikov A, Bouras A, Huang H BMC Genomics. 2020; 21(1):132.

PMID: 32033529 PMC: 7006399. DOI: 10.1186/s12864-020-6550-z.

Tenogenic modulating insider factor: Systematic assessment on the functions of tenomodulin gene.

Dex S, Lin D, Shukunami C, Docheva D Gene. 2016; 587(1):1-17.

PMID: 27129941 PMC: 4897592. DOI: 10.1016/j.gene.2016.04.051.

Aneurysm Development in Patients With Bicuspid Aortic Valve (BAV): Possible Connection to Repair Deficiency?.

Maleki S, Bjorck H, Paloschi V, Kjellqvist S, Folkersen L, Jackson V Aorta (Stamford). 2016; 1(1):13-22.

PMID: 26798668 PMC: 4682694. DOI: 10.12945/j.aorta.2013.12.011.

References

Shao R, Bao S, Bai X, Blanchette C, Anderson R, Dang T . Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004; 24(9):3992-4003. PMC: 387763. DOI: 10.1128/MCB.24.9.3992-4003.2004. View

Cowell S, Newby D, Prescott R, Bloomfield P, Reid J, Northridge D . A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med. 2005; 352(23):2389-97. DOI: 10.1056/NEJMoa043876. View

Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M . Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med. 2008; 205(2):295-303. PMC: 2271007. DOI: 10.1084/jem.20071297. View

Kaden J, Dempfle C, Grobholz R, Fischer C, Vocke D, Kilic R . Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol. 2005; 14(2):80-7. DOI: 10.1016/j.carpath.2005.01.002. View

Hiraki Y . [Molecular cloning of a novel cartilage-specific functional matrix, chondromodulin-I, and its role in endochondral bone formation]. Seikagaku. 1991; 63(12):1449-54. View

Hiraki Y, Shukunami C . Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin. Connect Tissue Res. 2005; 46(1):3-11. DOI: 10.1080/03008200590935547. View

Zijlstra A, Aimes R, Zhu D, Regazzoni K, Kupriyanova T, Seandel M . Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J Biol Chem. 2004; 279(26):27633-45. DOI: 10.1074/jbc.M313617200. View

Helske S, Kupari M, Lindstedt K, Kovanen P . Aortic valve stenosis: an active atheroinflammatory process. Curr Opin Lipidol. 2007; 18(5):483-91. DOI: 10.1097/MOL.0b013e3282a66099. View

Rossebo A, Pedersen T, Boman K, Brudi P, Chambers J, Egstrup K . Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008; 359(13):1343-56. DOI: 10.1056/NEJMoa0804602. View

10.

Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N . Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2009; 285(3):2028-39. PMC: 2804360. DOI: 10.1074/jbc.M109.051961. View

11.

Dangaria S, Ito Y, Walker C, Druzinsky R, Luan X, Diekwisch T . Extracellular matrix-mediated differentiation of periodontal progenitor cells. Differentiation. 2009; 78(2-3):79-90. PMC: 2744845. DOI: 10.1016/j.diff.2009.03.005. View

12.

Fondard O, Detaint D, Iung B, Choqueux C, Adle-Biassette H, Jarraya M . Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J. 2005; 26(13):1333-41. DOI: 10.1093/eurheartj/ehi248. View

13.

Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniyama Y, Hasegawa Y . Periostin as a novel factor responsible for ventricular dilation. Circulation. 2004; 110(13):1806-13. DOI: 10.1161/01.CIR.0000142607.33398.54. View

14.

Rajamannan N, Otto C . Targeted therapy to prevent progression of calcific aortic stenosis. Circulation. 2004; 110(10):1180-2. PMC: 3951855. DOI: 10.1161/01.CIR.0000140722.85490.EA. View

15.

Chalajour F, Treede H, Gehling U, Ebrahimnejad A, Boehm D, Riemer R . Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve. Exp Cell Res. 2007; 313(11):2326-35. DOI: 10.1016/j.yexcr.2007.02.033. View

16.

Aikawa E, Nahrendorf M, Sosnovik D, Lok V, Jaffer F, Aikawa M . Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007; 115(3):377-86. DOI: 10.1161/CIRCULATIONAHA.106.654913. View

17.

Ashraf S, Walsh D . Angiogenesis in osteoarthritis. Curr Opin Rheumatol. 2008; 20(5):573-80. DOI: 10.1097/BOR.0b013e3283103d12. View

18.

Kii I, Amizuka N, Minqi L, Kitajima S, Saga Y, Kudo A . Periostin is an extracellular matrix protein required for eruption of incisors in mice. Biochem Biophys Res Commun. 2006; 342(3):766-72. DOI: 10.1016/j.bbrc.2006.02.016. View

19.

Zhou H, Wang J, Elliott C, Wen W, Hamilton D, Conway S . Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation. J Cell Commun Signal. 2010; 4(2):99-107. PMC: 2876237. DOI: 10.1007/s12079-010-0090-2. View

20.

Nishiyama T, Kii I, Kashima T, Kikuchi Y, Ohazama A, Shimazaki M . Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing. PLoS One. 2011; 6(4):e18410. PMC: 3072397. DOI: 10.1371/journal.pone.0018410. View