Cis-trans Interactions of Cell Surface Receptors: Biological Roles and Structural Basis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 Aug 25

PMID 21863376

Citations 25

Authors

Werner Held

Roy A Mariuzza

Affiliations

Soon will be listed here.

Abstract

Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.

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