Mechanisms of NK Cell Activation: CD4(+) T Cells Enter the Scene

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 Aug 24

PMID 21861183

Citations 21

Authors

Franck Bihl

Claire Germain

Carmelo Luci

Veronique M Braud

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cells are innate lymphocytes involved in immunosurveillance through their cytotoxic activity and their capacity to secrete inflammatory cytokines. NK cell activation is necessary to initiate effector functions and results from a complex series of molecular and cellular events. We review here the signals that trigger NK cells and discuss recent findings showing that, besides antigen-presenting cells, T cells can play a central role in the initiation of NK cell activation in lymph nodes.

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