Anti-tumor and Immunomodulatory Activity of Resveratrol in Vitro and Its Potential for Combining with Cancer Immunotherapy

Overview

Journal Int Immunopharmacol

Specialties Allergy & Immunology
Pharmacology

Date 2011 Aug 23

PMID 21854876

Citations 8

Authors

Brenda L Soto

Jacquelyn A Hank

Soesiawati R Darjatmoko

Arthur S Polans

Eric M Yanke

Alexander L Rakhmilevich

Songwon Seo

KyungMann Kim

Ralph A Reisfeld

Stephen D Gillies

Paul M Sondel

Affiliations

Soon will be listed here.

Abstract

We evaluated the anti-tumor effect of Resveratrol (RV) on M21 and NXS2 tumor cell lines and its immunosuppressive activity on human and murine immune cells to determine the potential for combining RV and immunotherapy. In vitro, concentrations of RV≥25 mcM, inhibited cell proliferation, blocked DNA synthesis and induced G1 phase arrest in tumor and immune cells. RV at 12-50 mcM inhibited antibody dependent cell mediated cytotoxicity (ADCC) of tumor cells facilitated by the hu14.18-IL2 immunocytokine (IC). The in vivo anti-tumor and immunomodulating activity of RV given systemically were assessed in mice. Results showed that this RV regimen inhibited the growth of NXS2 tumors in vivo but did not appear to interfere with blood cell count, splenocyte or macrophage function. Thus, RV may be a candidate for combining with immunotherapy.

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