MicroRNAs Involved in the EGFR/PTEN/AKT Pathway in Gliomas

Overview

Journal J Neurooncol

Publisher Springer

Date 2011 Aug 16

PMID 21842313

Citations 18

Authors

Yingyi Wang

Xiefeng Wang

Junxia Zhang

Guan Sun

Hui Luo

Chunsheng Kang

Peiyu Pu

Tao Jiang

Ning Liu

Yongping You

Affiliations

Soon will be listed here.

Abstract

Gliomas are the most common type of malignant primary brain tumor. Despite advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not significantly improved. MicroRNAs (miRNAs), a class of non-coding RNAs, 21-25 nucleotides long, negatively regulate the expression of target genes by interacting with specific sites in mRNAs, and play a critical role in the development of gliomas. The EGFR/PTEN/AKT pathway is a promising target for anti-glioma therapy. Recent studies have showed that regulation of the EGFR/PTEN/AKT pathway by miRNAs plays a major role in glioma progression, indicating a novel way to investigate the tumorigenesis, diagnosis, and therapy of gliomas. Here, we focus on recent findings of miRNAs with respect to the EGFR/PTEN/AKT pathway in gliomas.

Citing Articles

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Targeting miR‑155‑5p and miR‑221‑3p by peptide nucleic acids induces caspase‑3 activation and apoptosis in temozolomide‑resistant T98G glioma cells.

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Higher expression of miR-133b is associated with better efficacy of erlotinib as the second or third line in non-small cell lung cancer patients.

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The Role of the Tumor Microenvironment in Glioblastoma: A Mathematical Model.

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Sang H, Jin Y, Zhang W, Chen L Med Sci Monit. 2016; 22:4066-4072.

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References

Tsai N, Lin Y, Wei L . MicroRNA mir-346 targets the 5'-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression. Biochem J. 2009; 424(3):411-8. DOI: 10.1042/BJ20090915. View

Loffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermuller J, Kretzschmar A . Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood. 2007; 110(4):1330-3. DOI: 10.1182/blood-2007-03-081133. View

Zhang Y, Chao T, Li R, Chen Y, Yan X, Gong Y . MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. J Mol Med (Berl). 2008; 87(1):43-51. DOI: 10.1007/s00109-008-0403-6. View

Jiang H, Shang X, Wu H, Gautam S, Al-Holou S, Li C . Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol. 2009; 8(1):25-33. PMC: 2833270. View

Shi L, Cheng Z, Zhang J, Li R, Zhao P, Fu Z . hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res. 2008; 1236:185-93. DOI: 10.1016/j.brainres.2008.07.085. View

Garzon R, Calin G, Croce C . MicroRNAs in Cancer. Annu Rev Med. 2009; 60:167-79. DOI: 10.1146/annurev.med.59.053006.104707. View

Papagiannakopoulos T, Shapiro A, Kosik K . MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res. 2008; 68(19):8164-72. DOI: 10.1158/0008-5472.CAN-08-1305. View

Maehama T, Dixon J . The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998; 273(22):13375-8. DOI: 10.1074/jbc.273.22.13375. View

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S . The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A. 2005; 102(52):19075-80. PMC: 1323209. DOI: 10.1073/pnas.0509603102. View

10.

Prevo R, Deutsch E, Sampson O, Diplexcito J, Cengel K, Harper J . Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity. Cancer Res. 2008; 68(14):5915-23. DOI: 10.1158/0008-5472.CAN-08-0757. View

11.

Kefas B, Comeau L, Erdle N, Montgomery E, Amos S, Purow B . Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro Oncol. 2010; 12(11):1102-12. PMC: 3098027. DOI: 10.1093/neuonc/noq080. View

12.

Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P . Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 2010; 90(2):144-55. DOI: 10.1038/labinvest.2009.126. View

13.

Nan Y, Han L, Zhang A, Wang G, Jia Z, Yang Y . MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res. 2010; 1359:14-21. DOI: 10.1016/j.brainres.2010.08.074. View

14.

Mayo L, Dixon J, Durden D, Tonks N, Donner D . PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2001; 277(7):5484-9. DOI: 10.1074/jbc.M108302200. View

15.

Godlewski J, Nowicki M, Bronisz A, Nuovo G, Palatini J, De Lay M . MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010; 37(5):620-32. PMC: 3125113. DOI: 10.1016/j.molcel.2010.02.018. View

16.

Denli A, Tops B, Plasterk R, Ketting R, Hannon G . Processing of primary microRNAs by the Microprocessor complex. Nature. 2004; 432(7014):231-5. DOI: 10.1038/nature03049. View

17.

Godlewski J, Nowicki M, Bronisz A, Williams S, Otsuki A, Nuovo G . Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008; 68(22):9125-30. DOI: 10.1158/0008-5472.CAN-08-2629. View

18.

Hresko R, Murata H, Mueckler M . Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes. J Biol Chem. 2003; 278(24):21615-22. DOI: 10.1074/jbc.M302937200. View

19.

Verhaak R, Hoadley K, Purdom E, Wang V, Qi Y, Wilkerson M . Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010; 17(1):98-110. PMC: 2818769. DOI: 10.1016/j.ccr.2009.12.020. View

20.

Kita D, Yonekawa Y, Weller M, Ohgaki H . PIK3CA alterations in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 2007; 113(3):295-302. DOI: 10.1007/s00401-006-0186-1. View