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Genetic Linkage and Complex Diseases, with Special Reference to Psychiatric Disorders

Overview
Journal Genet Epidemiol
Specialties Genetics
Public Health
Date 1990 Jan 1
PMID 2184091
Citations 51
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Abstract

Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic-depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.

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