Autocrine and Paracrine Growth Regulation of Breast Cancer: Clinical Implications

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1990 Jan 1

PMID 2183891

Citations 18

Authors

C K Osborne

C L Arteaga

Affiliations

Soon will be listed here.

Abstract

Research using experimental models of human breast cancer has broadened our understanding of the possible biochemical pathways regulating breast cancer growth. Breast cancer cells express receptors for and respond to a variety of steroid and polypeptide hormones and growth factors. Specific oncogenes are also expressed in breast cancer cells, and levels of expression may relate to tumor growth and aggressiveness. Recent studies have shown that breast cancer cells can even synthesize and secrete various growth factors that could stimulate tumor growth through autocrine and/or paracrine mechanisms. Secretion of some of these growth factors is regulated by estrogen, providing a possible mechanism for estrogen induced growth. Knowledge of these growth regulatory pathways has potentially important clinical implications. Blockade of these pathways offers new possible treatment strategies, much as antiestrogens have been used to inhibit tumor growth. Quantification of the expression of certain oncogenes, growth factor receptors, or the growth factors themselves, may provide prognostic information for the individual patient. Finally, it is plausible that measurement of these tumor products in body fluids might provide tumor markers that are useful in the diagnosis and treatment of breast cancer.

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References

Huff K, Knabbe C, Lindsey R, Kaufman D, Bronzert D, Lippman M . Multihormonal regulation of insulin-like growth factor-I-related protein in MCF-7 human breast cancer cells. Mol Endocrinol. 1988; 2(3):200-8. DOI: 10.1210/mend-2-3-200. View

Furlanetto R, DiCarlo J . Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture. Cancer Res. 1984; 44(5):2122-8. View

Hanauske A, Arteaga C, Clark G, Buchok J, Marshall M, Hazarika P . Determination of transforming growth factor activity in effusions from cancer patients. Cancer. 1988; 61(9):1832-7. DOI: 10.1002/1097-0142(19880501)61:9<1832::aid-cncr2820610919>3.0.co;2-j. View

Nicholson S, Sainsbury J, Needham G, Chambers P, Farndon J, Harris A . Quantitative assays of epidermal growth factor receptor in human breast cancer: cut-off points of clinical relevance. Int J Cancer. 1988; 42(1):36-41. DOI: 10.1002/ijc.2910420108. View

WELSCH C, Nagasawa H . Prolactin and murine mammary tumorigenesis: a review. Cancer Res. 1977; 37(4):951-63. View

Clemmons D, Elgin R, Han V, Casella S, DErcole A, Van Wyk J . Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I. J Clin Invest. 1986; 77(5):1548-56. PMC: 424558. DOI: 10.1172/JCI112470. View

Lippman M, Dickson R, Gelmann E, Rosen N, Knabbe C, Bates S . Growth regulation of human breast carcinoma occurs through regulated growth factor secretion. J Cell Biochem. 1987; 35(1):1-16. DOI: 10.1002/jcb.240350102. View

Slamon D, Clark G, Wong S, Levin W, Ullrich A, McGuire W . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235(4785):177-82. DOI: 10.1126/science.3798106. View

Massague J . The TGF-beta family of growth and differentiation factors. Cell. 1987; 49(4):437-8. DOI: 10.1016/0092-8674(87)90443-0. View

10.

Picard O, Rolland Y, Poupon M . Fibroblast-dependent tumorigenicity of cells in nude mice: implication for implantation of metastases. Cancer Res. 1986; 46(7):3290-4. View

11.

Osborene C, Hamilton B, Nover M . Receptor binding and processing of epidermal growth factor by human breast cancer cells. J Clin Endocrinol Metab. 1982; 55(1):86-93. DOI: 10.1210/jcem-55-1-86. View

12.

Tucker R, Volkenant M, Branum E, Moses H . Comparison of intra- and extracellular transforming growth factors from nontransformed and chemically transformed mouse embryo cells. Cancer Res. 1983; 43(4):1581-6. View

13.

Ikeda T, Danielpour D, Sirbasku D . Characterization of a sheep pituitary-derived growth factor for rat and human mammary tumor cells. J Cell Biochem. 1984; 25(4):213-29. DOI: 10.1002/jcb.240250404. View

14.

Nunez A, Jakowlev S, Briand J, Gaire M, Krust A, Rio M . Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7. Endocrinology. 1987; 121(5):1759-65. DOI: 10.1210/endo-121-5-1759. View

15.

Arteaga C, Tandon A, Von Hoff D, Osborne C . Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res. 1988; 48(14):3898-904. View

16.

Cuttitta F, Carney D, Mulshine J, Moody T, Fedorko J, Fischler A . Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature. 1985; 316(6031):823-6. DOI: 10.1038/316823a0. View

17.

Masui H, Kawamoto T, Sato J, Wolf B, Sato G, Mendelsohn J . Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res. 1984; 44(3):1002-7. View

18.

Knabbe C, Lippman M, Wakefield L, Flanders K, Kasid A, Derynck R . Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell. 1987; 48(3):417-28. DOI: 10.1016/0092-8674(87)90193-0. View

19.

Roberts A, Anzano M, Wakefield L, Roche N, Stern D, Sporn M . Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A. 1985; 82(1):119-23. PMC: 396983. DOI: 10.1073/pnas.82.1.119. View

20.

Sporn M, Roberts A, Wakefield L, Assoian R . Transforming growth factor-beta: biological function and chemical structure. Science. 1986; 233(4763):532-4. DOI: 10.1126/science.3487831. View