The MicroRNA Body Map: Dissecting MicroRNA Function Through Integrative Genomics

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2011 Aug 13

PMID 21835775

Citations 48

Authors

Pieter Mestdagh

Steve Lefever

Filip Pattyn

Dana Ridzon

Erik Fredlund

Annelies Fieuw

Mate Ongenaert

Joelle Vermeulen

Anne De Paepe

Linda Wong

Frank Speleman

Caifu Chen

Jo Vandesompele

Affiliations

Soon will be listed here.

Abstract

While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of corresponding miRNA and mRNA gene expression levels, miRNA target prediction, transcription factor target prediction and mechanistic models of gene network regulation. Predicted miRNA functions were either validated experimentally or compared to published data. The predicted miRNA functions are accessible in the miRNA bodymap, an interactive online compendium and mining tool of high-dimensional newly generated and published miRNA expression profiles. The miRNA bodymap enables prioritization of candidate miRNAs based on their expression pattern or functional annotation across tissue or disease subgroup. The miRNA bodymap project provides users with a single one-stop data-mining solution and has great potential to become a community resource.

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