Leveraging the Power of Ultrasound for Therapeutic Design and Optimization

Overview

Journal J Control Release

Specialty Pharmacology

Date 2011 Aug 13

PMID 21835212

Citations 13

Authors

Charles F Caskey

Xiaowen Hu

Katherine W Ferrara

Affiliations

Soon will be listed here.

Abstract

Contrast agent-enhanced ultrasound can facilitate personalized therapeutic strategies by providing the technology to measure local blood flow rate, to selectively image receptors on the vascular endothelium, and to enhance localized drug delivery. Ultrasound contrast agents are micron-diameter encapsulated bubbles that circulate within the vascular compartment and can be selectively imaged with ultrasound. Microbubble transport-based estimates of local blood flow can quantify changes resulting from anti-angiogenic therapies and facilitate differentiation of angiogenic mechanisms. Microbubbles that are conjugated with targeting ligands attach to endothelial surface receptors that are upregulated in disease, providing high signal-to-noise ratio images of pathological vasculature. In addition to imaging applications, microbubbles can be used to enhance localized gene and drug delivery, either by changing membrane and vascular permeability or by carrying and locally releasing cargo. Our goal in this review is to provide an overview of the use of contrast-enhanced ultrasound methodologies in the design and evaluation of therapeutic strategies with emphases on quantitative blood flow mapping, molecular imaging, and enhanced drug delivery.

Citing Articles

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References

Ponce A, Viglianti B, Yu D, Yarmolenko P, Michelich C, Woo J . Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. J Natl Cancer Inst. 2007; 99(1):53-63. DOI: 10.1093/jnci/djk005. View

Rapoport N, Kennedy A, Shea J, Scaife C, Nam K . Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging. Mol Pharm. 2009; 7(1):22-31. PMC: 2815246. DOI: 10.1021/mp900128x. View

Villanueva F, Lu E, Bowry S, Kilic S, Tom E, Wang J . Myocardial ischemic memory imaging with molecular echocardiography. Circulation. 2007; 115(3):345-52. PMC: 4142344. DOI: 10.1161/CIRCULATIONAHA.106.633917. View

Morgan K, Allen J, Dayton P, Chomas J, Klibaov A, Ferrara K . Experimental and theoretical evaluation of microbubble behavior: effect of transmitted phase and bubble size. IEEE Trans Ultrason Ferroelectr Freq Control. 2008; 47(6):1494-509. DOI: 10.1109/58.883539. View

Burns P, Wilson S, Simpson D . Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol. 2000; 35(1):58-71. DOI: 10.1097/00004424-200001000-00007. View

Kheirolomoom A, Dayton P, Lum A, Little E, Paoli E, Zheng H . Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle. J Control Release. 2007; 118(3):275-84. PMC: 2662343. DOI: 10.1016/j.jconrel.2006.12.015. View

Guenther F, von Zur Muhlen C, Ferrante E, Grundmann S, Bode C, Klibanov A . An ultrasound contrast agent targeted to P-selectin detects activated platelets at supra-arterial shear flow conditions. Invest Radiol. 2010; 45(10):586-91. PMC: 3426507. DOI: 10.1097/RLI.0b013e3181ed1b3b. View

Suzuki R, Oda Y, Utoguchi N, Namai E, Taira Y, Okada N . A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy. J Control Release. 2008; 133(3):198-205. DOI: 10.1016/j.jconrel.2008.10.015. View

Lassau N, Chebil M, Chami L, Bidault S, Girard E, Roche A . Dynamic contrast-enhanced ultrasonography (DCE-US): a new tool for the early evaluation of antiangiogenic treatment. Target Oncol. 2010; 5(1):53-8. DOI: 10.1007/s11523-010-0136-7. View

10.

Schumann P, Christiansen J, Quigley R, McCreery T, Sweitzer R, Unger E . Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi. Invest Radiol. 2002; 37(11):587-93. DOI: 10.1097/00004424-200211000-00001. View

11.

Couture O, Faivre M, Pannacci N, Babataheri A, Servois V, Tabeling P . Ultrasound internal tattooing. Med Phys. 2011; 38(2):1116-23. DOI: 10.1118/1.3548068. View

12.

Chappell J, Song J, Burke C, Klibanov A, Price R . Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small. 2008; 4(10):1769-77. PMC: 2716217. DOI: 10.1002/smll.200800806. View

13.

Willmann J, Lutz A, Paulmurugan R, Patel M, Chu P, Rosenberg J . Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology. 2008; 248(3):936-44. PMC: 2798094. DOI: 10.1148/radiol.2483072231. View

14.

Watanabe Y, Aoi A, Horie S, Tomita N, Mori S, Morikawa H . Low-intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin. Cancer Sci. 2008; 99(12):2525-31. PMC: 11159926. DOI: 10.1111/j.1349-7006.2008.00989.x. View

15.

Caskey C, Qin S, Dayton P, Ferrara K . Microbubble tunneling in gel phantoms. J Acoust Soc Am. 2009; 125(5):EL183-9. PMC: 2736761. DOI: 10.1121/1.3097679. View

16.

Dayton P, Allen J, Ferrara K . The magnitude of radiation force on ultrasound contrast agents. J Acoust Soc Am. 2002; 112(5 Pt 1):2183-92. DOI: 10.1121/1.1509428. View

17.

Leong-Poi H, Christiansen J, Klibanov A, Kaul S, Lindner J . Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003; 107(3):455-60. DOI: 10.1161/01.cir.0000044916.05919.8b. View

18.

Wagner A, Mahrholdt H, Holly T, Elliott M, Regenfus M, Parker M . Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003; 361(9355):374-9. DOI: 10.1016/S0140-6736(03)12389-6. View

19.

Meltzer R . Food and Drug Administration ultrasound device regulation: the output display standard, the "mechanical index," and ultrasound safety. J Am Soc Echocardiogr. 1996; 9(2):216-20. DOI: 10.1016/s0894-7317(96)90035-8. View

20.

Serfis , Katzenberger , Williams , Tran . Association of Blood Clotting Factors I and VII with Phospholipid Monolayers at the Air-Water Interface. J Colloid Interface Sci. 1999; 215(2):356-363. DOI: 10.1006/jcis.1999.6280. View