Casting a Net on Dendritic Spines: the Extracellular Matrix and Its Receptors

Overview

Journal Dev Neurobiol

Specialties Biology
Neurology

Date 2011 Aug 12

PMID 21834084

Citations 38

Authors

Lorraine E Dansie

Iryna M Ethell

Affiliations

Soon will be listed here.

Abstract

Dendritic spines are dynamic structures that accommodate the majority of excitatory synapses in the brain and are influenced by extracellular signals from presynaptic neurons, glial cells, and the extracellular matrix (ECM). The ECM surrounds dendritic spines and extends into the synaptic cleft, maintaining synapse integrity as well as mediating trans-synaptic communications between neurons. Several scaffolding proteins and glycans that compose the ECM form a lattice-like network, which serves as an attractive ground for various secreted glycoproteins, lectins, growth factors, and enzymes. ECM components can control dendritic spines through the interactions with their specific receptors or by influencing the functions of other synaptic proteins. In this review, we focus on ECM components and their receptors that regulate dendritic spine development and plasticity in the normal and diseased brain.

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References

Pawlak R, Rao B, Melchor J, Chattarji S, McEwen B, Strickland S . Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. Proc Natl Acad Sci U S A. 2005; 102(50):18201-6. PMC: 1312427. DOI: 10.1073/pnas.0509232102. View

Sia G, Beique J, Rumbaugh G, Cho R, Worley P, Huganir R . Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron. 2007; 55(1):87-102. DOI: 10.1016/j.neuron.2007.06.020. View

Lendvai B, Stern E, Chen B, Svoboda K . Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo. Nature. 2000; 404(6780):876-81. DOI: 10.1038/35009107. View

Ruoslahti E . Integrins. J Clin Invest. 1991; 87(1):1-5. PMC: 294975. DOI: 10.1172/JCI114957. View

Ethell I, Irie F, Kalo M, Couchman J, Pasquale E, Yamaguchi Y . EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron. 2001; 31(6):1001-13. DOI: 10.1016/s0896-6273(01)00440-8. View

Zuo Y, Lin A, Chang P, Gan W . Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Neuron. 2005; 46(2):181-9. DOI: 10.1016/j.neuron.2005.04.001. View

Lin K, Sloniowski S, Ethell D, Ethell I . Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem. 2008; 283(43):28969-79. PMC: 2570862. DOI: 10.1074/jbc.M804401200. View

Ziv N, Smith S . Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron. 1996; 17(1):91-102. DOI: 10.1016/s0896-6273(00)80283-4. View

Dityatev A, Schachner M . Extracellular matrix molecules and synaptic plasticity. Nat Rev Neurosci. 2003; 4(6):456-68. DOI: 10.1038/nrn1115. View

10.

Cunningham L, Wetzel M, Rosenberg G . Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia. 2005; 50(4):329-339. DOI: 10.1002/glia.20169. View

11.

Liesi P, Dahl D, Vaheri A . Laminin is produced by early rat astrocytes in primary culture. J Cell Biol. 1983; 96(3):920-4. PMC: 2112419. DOI: 10.1083/jcb.96.3.920. View

12.

Tian L, Stefanidakis M, Ning L, Van Lint P, Nyman-Huttunen H, Libert C . Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol. 2007; 178(4):687-700. PMC: 2064474. DOI: 10.1083/jcb.200612097. View

13.

Nimchinsky E, Yasuda R, Oertner T, Svoboda K . The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines. J Neurosci. 2004; 24(8):2054-64. PMC: 6730404. DOI: 10.1523/JNEUROSCI.5066-03.2004. View

14.

Skaar D, Shao Y, Haines J, Stenger J, Jaworski J, Martin E . Analysis of the RELN gene as a genetic risk factor for autism. Mol Psychiatry. 2004; 10(6):563-71. DOI: 10.1038/sj.mp.4001614. View

15.

Godyna S, Liau G, Popa I, Stefansson S, Argraves W . Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. J Cell Biol. 1995; 129(5):1403-10. PMC: 2120467. DOI: 10.1083/jcb.129.5.1403. View

16.

Dwivedi A, Slater S, George S . MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation. Cardiovasc Res. 2008; 81(1):178-86. DOI: 10.1093/cvr/cvn278. View

17.

Chang M, Park J, Pelkey K, Grabenstatter H, Xu D, Linden D . Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci. 2010; 13(9):1090-7. PMC: 2949072. DOI: 10.1038/nn.2621. View

18.

Bezakova G, Ruegg M . New insights into the roles of agrin. Nat Rev Mol Cell Biol. 2003; 4(4):295-308. DOI: 10.1038/nrm1074. View

19.

Woods A . Syndecans: transmembrane modulators of adhesion and matrix assembly. J Clin Invest. 2001; 107(8):935-41. PMC: 199565. DOI: 10.1172/JCI12802. View

20.

Xu D, Hopf C, Reddy R, Cho R, Guo L, Lanahan A . Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron. 2003; 39(3):513-28. DOI: 10.1016/s0896-6273(03)00463-x. View