Studies on Brahma Rasayana in Male Swiss Albino Mice: Chromosomal Aberrations and Sperm Abnormalities

Overview

Journal J Ayurveda Integr Med

Publisher Elsevier

Date 2011 Aug 11

PMID 21829300

Citations 4

Authors

K P Guruprasad

Roshan Mascarenhas

P M Gopinath

K Satyamoorthy

Affiliations

Soon will be listed here.

Abstract

Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently used as rejuvenant therapy to overcome many discomforts and prevent diseases. It has been reported that rasayanas have immunomodulatory, antioxidant and antitumor functions. However, the genotoxic potential of many rasayanas remains to be evaluated. The present study was undertaken to assess the role of Brahma rasayana(BR) on genotoxicity in vivo in a mouse test system. The older mice (9 months) were orally fed with rasayana for 8 weeks. The treated groups showed no signs of dose-dependent toxicity at the dosage levels tested. The body weight loss/gain and feed consumption were unaffected at tested doses. Furthermore, sperm abnormalities and chromosomal aberrations were insignificant in the treatment group when compared to controls. However, there was a marginal increase in sperm count in the BR treated animals. These findings clearly indicate that there are no observed adverse genotoxic effects elicited by BR in experimental animals such as mice.

Citing Articles

Successful Treatment of Sperm DNA Fragmentation Through Ayurveda Rasayana Therapy: A Case Study.

Bendale V, Chaganti S, Pandav R, Pawar D J Reprod Infertil. 2024; 25(1):60-65.

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Understanding the effects of Abhraka Bhasma on genotoxicity and its DNA repair potential in mouse model.

Kulala D, Prasad K, Reddy P, Maruthiyodan S, Joshi M, Satyamoorthy K J Ayurveda Integr Med. 2022; 14(2):100598.

PMID: 35973910 PMC: 10307683. DOI: 10.1016/j.jaim.2022.100598.

Aqueous ethanolic extract of Tinospora cordifolia as a potential candidate for differentiation based therapy of glioblastomas.

Mishra R, Kaur G PLoS One. 2013; 8(10):e78764.

PMID: 24205314 PMC: 3811968. DOI: 10.1371/journal.pone.0078764.

Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone marrow cells.

Guruprasad K, Subramanian A, Singh V, Sharma R, Gopinath P, Sewram V BMC Complement Altern Med. 2012; 12:113.

PMID: 22853637 PMC: 3457898. DOI: 10.1186/1472-6882-12-113.

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