Genetic Architecture of Prostate Cancer in the Ashkenazi Jewish Population

Overview

Journal Br J Cancer

Specialty Oncology

Date 2011 Aug 11

PMID 21829199

Citations 9

Authors

J Vijai

T Kirchhoff

D Gallagher

N Hamel

S Guha

A Darvasi

T Lencz

W D Foulkes

K Offit

R J Klein

Affiliations

Soon will be listed here.

Abstract

Background: Recently, numerous prostate cancer risk loci have been identified, some of which show association in specific populations. No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population.

Methods: A total of 29 known prostate cancer risk SNPs were genotyped in 963 prostate cancer cases and 613 controls of AJ ancestry. These data were combined with data from 1241 additional Ashkenazi controls and tested for association with prostate cancer. Correction for multiple testing was performed using the false discovery rate procedure.

Results: Ten of twenty-three SNPs that passed quality control procedures were associated with prostate cancer risk at a false discovery rate of 5%. Of these, nine were originally discovered in studies of individuals of European ancestry. Based on power calculations, the number of significant associations observed is not surprising.

Conclusion: We see no convincing evidence that the genetic architecture of prostate cancer in the AJ population is substantively different from that observed in other populations of European ancestry.

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References

Bersaglieri T, Sabeti P, Patterson N, Vanderploeg T, Schaffner S, Drake J . Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet. 2004; 74(6):1111-20. PMC: 1182075. DOI: 10.1086/421051. View

Olshen A, Gold B, Lohmueller K, Struewing J, Satagopan J, Stefanov S . Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet. 2008; 9:14. PMC: 2259380. DOI: 10.1186/1471-2156-9-14. View

Hooker S, Hernandez W, Chen H, Robbins C, Torres J, Ahaghotu C . Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate. 2009; 70(3):270-5. DOI: 10.1002/pros.21061. View

Robbins C, Torres J, Hooker S, Bonilla C, Hernandez W, Candreva A . Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Genome Res. 2007; 17(12):1717-22. PMC: 2099580. DOI: 10.1101/gr.6782707. View

Mitchell M, Gregersen P, Johnson S, Parsons R, Vlahov D . The New York Cancer Project: rationale, organization, design, and baseline characteristics. J Urban Health. 2004; 81(2):301-10. PMC: 3456454. DOI: 10.1093/jurban/jth116. View

Waters K, Le Marchand L, Kolonel L, Monroe K, Stram D, Henderson B . Generalizability of associations from prostate cancer genome-wide association studies in multiple populations. Cancer Epidemiol Biomarkers Prev. 2009; 18(4):1285-9. PMC: 2917607. DOI: 10.1158/1055-9965.EPI-08-1142. View

Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson J, Thorleifsson G, Manolescu A . Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007; 39(8):977-83. DOI: 10.1038/ng2062. View

Gudmundsson J, Sulem P, Rafnar T, Bergthorsson J, Manolescu A, Gudbjartsson D . Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008; 40(3):281-3. PMC: 3598012. DOI: 10.1038/ng.89. View

Price A, Butler J, Patterson N, Capelli C, Pascali V, Scarnicci F . Discerning the ancestry of European Americans in genetic association studies. PLoS Genet. 2008; 4(1):e236. PMC: 2211542. DOI: 10.1371/journal.pgen.0030236. View

10.

Yeager M, Chatterjee N, Ciampa J, Jacobs K, Gonzalez-Bosquet J, Hayes R . Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet. 2009; 41(10):1055-7. PMC: 3430510. DOI: 10.1038/ng.444. View

11.

Klein R . Power analysis for genome-wide association studies. BMC Genet. 2007; 8:58. PMC: 2042984. DOI: 10.1186/1471-2156-8-58. View

12.

Kirchhoff T, Kauff N, Mitra N, Nafa K, Huang H, Palmer C . BRCA mutations and risk of prostate cancer in Ashkenazi Jews. Clin Cancer Res. 2004; 10(9):2918-21. DOI: 10.1158/1078-0432.ccr-03-0604. View

13.

Yamada H, Penney K, Takahashi H, Katoh T, Yamano Y, Yamakado M . Replication of prostate cancer risk loci in a Japanese case-control association study. J Natl Cancer Inst. 2009; 101(19):1330-6. DOI: 10.1093/jnci/djp287. View

14.

Tischkowitz M, Yilmaz A, Chen L, Karyadi D, Novak D, Kirchhoff T . Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer. Cancer Lett. 2008; 270(1):173-80. PMC: 2969172. DOI: 10.1016/j.canlet.2008.05.006. View

15.

Eeles R, Kote-Jarai Z, Olama A, Giles G, Guy M, Severi G . Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009; 41(10):1116-21. PMC: 2846760. DOI: 10.1038/ng.450. View

16.

Gudmundsson J, Sulem P, Gudbjartsson D, Blondal T, Gylfason A, Agnarsson B . Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet. 2009; 41(10):1122-6. PMC: 3562712. DOI: 10.1038/ng.448. View

17.

Haiman C, Patterson N, Freedman M, Myers S, Pike M, Waliszewska A . Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007; 39(5):638-44. PMC: 2638766. DOI: 10.1038/ng2015. View

18.

Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, Garber J . Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A. 2008; 105(11):4340-5. PMC: 2393811. DOI: 10.1073/pnas.0800441105. View

19.

Kim S, Cheng Y, Hsu F, Jin T, Kader A, Zheng S . Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. Prostate. 2010; 70(16):1729-38. PMC: 3013361. DOI: 10.1002/pros.21208. View

20.

Gudmundsson J, Sulem P, Manolescu A, Amundadottir L, Gudbjartsson D, Helgason A . Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet. 2007; 39(5):631-7. DOI: 10.1038/ng1999. View