Mammalian Metallothionein in Toxicology, Cancer, and Cancer Chemotherapy

Overview

Journal J Biol Inorg Chem

Publisher Springer

Specialty Biochemistry

Date 2011 Aug 9

PMID 21822976

Citations 24

Authors

Mohammad Namdarghanbari

William Wobig

Susan Krezoski

Niloofar M Tabatabai

David H Petering

Affiliations

Soon will be listed here.

Abstract

The present paper centers on mammalian metallothionein 1 and 2 in relationship to cell and tissue injury beginning with its reaction with Cd²⁺ and then considering its role in the toxicology and chemotherapy of both metals and non-metal electrophiles and oxidants. Intertwined is a consideration of MTs role in tumor cell Zn²⁺ metabolism. The paper updates and expands on our recent review by Petering et al. (Met Ions Life Sci 5:353-398, 2009).

Citing Articles

Screening Methods to Discover the FDA-Approved Cancer Drug Encorafenib as Optimally Selective for Metallothionein Gene Loss Ovarian Cancer.

Rees A, Villamor E, Evans D, Gooz M, Fallon C, Mina-Abouda M Genes (Basel). 2025; 16(1.

PMID: 39858588 PMC: 11764637. DOI: 10.3390/genes16010042.

Macrophage metallothioneins participate in the antileishmanial activity of antimonials.

Vargas D, Gregory D, Koren R, Zilberstein D, Belew A, El-Sayed N Front Parasitol. 2024; 2.

PMID: 38239429 PMC: 10795579. DOI: 10.3389/fpara.2023.1242727.

Arsenic binding to human metallothionein-3.

Yuan A, Stillman M Chem Sci. 2023; 14(21):5756-5767.

PMID: 37265731 PMC: 10231319. DOI: 10.1039/d3sc00400g.

An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies.

Michalczyk K, Kapczuk P, Witczak G, Tousty P, Bosiacki M, Kurzawski M Genes (Basel). 2023; 14(3).

PMID: 36981043 PMC: 10048541. DOI: 10.3390/genes14030773.

Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.

Kalyan G, Slusser-Nore A, Dunlevy J, Bathula C, Shabb J, Muhonen W PLoS One. 2022; 17(5):e0267599.

PMID: 35503771 PMC: 9064079. DOI: 10.1371/journal.pone.0267599.

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