Osteolipoma: Radiological, Pathological, and Cytogenetic Analysis of Three Cases

Overview

Journal Skeletal Radiol

Specialties Orthopedics
Radiology

Date 2011 Aug 9

PMID 21822651

Citations 15

Authors

Karen J Fritchie

Jordan B Renner

Kathleen W Rao

Robert J Esther

Affiliations

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Abstract

Osteolipoma is a rare variant of lipoma consisting of mature adipose tissue and mature lamellar bone. The presence of non-fatty elements may lead to a wide differential diagnosis on radiology including benign and malignant lipomatous and nonlipomatous entities. The pathological diagnosis is also confounded by the presence of heterologous differentiation. Fortunately, most lipomas harbor classic cytogenetic aberrations, and the finding of translocations involving 12q13-15 may aid in the correct diagnosis. We report three cases of osteolipoma with radiological, histological, and cytogenetic correlation.

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References

Gaskin C, Helms C . Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. AJR Am J Roentgenol. 2004; 182(3):733-9. DOI: 10.2214/ajr.182.3.1820733. View

Sheff J, Wang S . Extraskeletal osteochondroma of the foot. J Foot Ankle Surg. 2005; 44(1):57-9. DOI: 10.1053/j.jfas.2004.11.002. View

Gayle E, Morrison W, Carrino J, PARSONS T, Liang C, Stevenson A . Extraskeletal osteochondroma of the foot. Skeletal Radiol. 1999; 28(10):594-8. DOI: 10.1007/s002560050626. View

Castilho R, Squarize C, Nunes F, Pinto Junior D . Osteolipoma: a rare lesion in the oral cavity. Br J Oral Maxillofac Surg. 2004; 42(4):363-4. DOI: 10.1016/j.bjoms.2004.04.001. View

Petit M, Swarts S, Bridge J, Van de Ven W . Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer Genet Cytogenet. 1998; 106(1):18-23. DOI: 10.1016/s0165-4608(98)00038-7. View

Orui H, Ishikawa A, Tsuchiya T, Takahara M, Ito M, Ogino T . Chondro-osseous differentiation in fat tissue tumors: magnetic resonance imaging with pathological correlation. Skeletal Radiol. 2000; 29(8):459-65. DOI: 10.1007/s002560000241. View

Rubin B, Fletcher C . The cytogenetics of lipomatous tumours. Histopathology. 1997; 30(6):507-11. DOI: 10.1046/j.1365-2559.1997.5680797.x. View

Heffernan E, Lefaivre K, Munk P, Nielsen T, Masri B . Ossifying lipoma of the thigh. Br J Radiol. 2008; 81(968):e207-10. DOI: 10.1259/bjr/38805072. View

Rosai J, Akerman M, Dal Cin P, DeWever I, Fletcher C, Mandahl N . Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (a report of the CHAMP Study Group). Am J Surg Pathol. 1996; 20(10):1182-9. DOI: 10.1097/00000478-199610000-00002. View

10.

Matsui Y, Hasegawa T, Kubo T, Goto T, Yukata K, Endo K . Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript. J Clin Pathol. 2006; 59(4):434-6. PMC: 1860369. DOI: 10.1136/jcp.2005.026393. View

11.

Galant J, Marti-Bonmati L, Saez F, Soler R, Alcala-Santaella R, Navarro M . The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma. Eur Radiol. 2003; 13(2):337-43. DOI: 10.1007/s00330-002-1463-6. View

12.

Demiralp B, Alderete J, Kose O, Ozcan A, Cicek I, Basbozkurt M . Osteolipoma independent of bone tissue: a case report. Cases J. 2009; 2:8711. PMC: 2769468. DOI: 10.4076/1757-1626-2-8711. View

13.

Bansal M, Goldman A, DiCarlo E, McCormack R . Soft tissue chondromas: diagnosis and differential diagnosis. Skeletal Radiol. 1993; 22(5):309-15. DOI: 10.1007/BF00198387. View

14.

Boltze C, Hribaschek A, Lippert H, Roessner A . Intermuscular chondrolipoma of the thigh: the diagnostic way of a rare entity. Pathol Res Pract. 2003; 199(7):503-7. DOI: 10.1078/0344-0338-00454. View

15.

Val-Bernal J, Val D, Garijo M, Vega A, Gonzalez-Vela M . Subcutaneous ossifying lipoma: case report and review of the literature. J Cutan Pathol. 2007; 34(10):788-92. DOI: 10.1111/j.1600-0560.2006.00704.x. View