Microvascular Endothelial Cell Heterogeneity: Interactions with Leukocytes and Tumor Cells

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 1990 Feb 1

PMID 2182212

Citations 34

Authors

P N Belloni

R J Tressler

Affiliations

Soon will be listed here.

Abstract

Endothelium constitutes a highly specialized organ that lines the vascular system and lymphatic channels. This organ is a complex network of arteries, veins, and microvessels that differ in size, structure, and function. The unique and strategic location imposes functional demands on the endothelium that are far greater than just being a passive barrier. Endothelial cells have the ability to differentiate both in structure and function in response to the needs of diverse tissue environments, making this organ extremely heterogeneous. Although vascular endothelial cells share certain common properties, they differ in regard to structure, antigenic and cell surface determinants, adhesion molecules, and metabolic function. The unique cell surface profiles expressed by endothelial cells in different tissue locations can be recognized by specific populations of circulating leukocytes or tumor cells, which contribute to their arrest and invasion patterns. This article attempts to review our current understanding of endothelial cell heterogeneity and its significance to patterns of leukocyte and tumor cell trafficking.

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References

Jaffe E, HOYER L, Nachman R . Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest. 1973; 52(11):2757-64. PMC: 302543. DOI: 10.1172/JCI107471. View

Phondke G, Madyastha K, Madyastha P, Barth R . Relationship between concanavalin A-induced agglutinability of murine leukemia cells and their propensity to form heterotypic aggregates with syngeneic lymphoid cells. J Natl Cancer Inst. 1981; 66(4):643-7. View

Del Vecchio P, Smith J . Expression of angiotensin-converting enzyme activity in cultured pulmonary artery endothelial cells. J Cell Physiol. 1981; 108(3):337-45. DOI: 10.1002/jcp.1041080307. View

Nicolson G . Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells. Biochim Biophys Acta. 1982; 695(2):113-76. DOI: 10.1016/0304-419x(82)90020-8. View

Ruggeri Z, De Marco L, Gatti L, Bader R, Montgomery R . Platelets have more than one binding site for von Willebrand factor. J Clin Invest. 1983; 72(1):1-12. PMC: 1129155. DOI: 10.1172/jci110946. View

Pierschbacher M, Ruoslahti E . Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem. 1987; 262(36):17294-8. View

Colucci M, Balconi G, Lorenzet R, Pietra A, Locati D, Donati M . Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest. 1983; 71(6):1893-6. PMC: 370395. DOI: 10.1172/jci110945. View

Weksler B, Ley C, Jaffe E . Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187. J Clin Invest. 1978; 62(5):923-30. PMC: 371849. DOI: 10.1172/JCI109220. View

Alroy J, Goyal V, Skutelsky E . Lectin histochemistry of mammalian endothelium. Histochemistry. 1987; 86(6):603-7. DOI: 10.1007/BF00489554. View

10.

Roos E, Tulp A, Middelkoop O, Van de Pavert I . Interactions between lymphoid tumor cells and isolated liver endothelial cells. J Natl Cancer Inst. 1984; 72(5):1173-80. View

11.

Bowman P, Betz A, Ar D, Wolinsky J, Penney J, Shivers R . Primary culture of capillary endothelium from rat brain. In Vitro. 1981; 17(4):353-62. DOI: 10.1007/BF02618147. View

12.

Nicolson G . Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev. 1988; 7(2):143-88. DOI: 10.1007/BF00046483. View

13.

Gimbrone Jr M . Culture of vascular endothelium. Prog Hemost Thromb. 1976; 3:1-28. View

14.

Little D, Said J, Siegel R, Fealy M, Fishbein M . Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin. J Pathol. 1986; 149(2):89-95. DOI: 10.1002/path.1711490203. View

15.

Pardridge W, Yang J, Eisenberg J, Mietus L . Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein. J Cereb Blood Flow Metab. 1986; 6(2):203-11. DOI: 10.1038/jcbfm.1986.33. View

16.

Bizios R, Lai L, Cooper J, Del Vecchio P, Malik A . Thrombin-induced adherence of neutrophils to cultured endothelial monolayers: increased endothelial adhesiveness. J Cell Physiol. 1988; 134(2):275-80. DOI: 10.1002/jcp.1041340214. View

17.

Hynes R . Integrins: a family of cell surface receptors. Cell. 1987; 48(4):549-54. DOI: 10.1016/0092-8674(87)90233-9. View

18.

Madri J, Pratt B . Endothelial cell-matrix interactions: in vitro models of angiogenesis. J Histochem Cytochem. 1986; 34(1):85-91. DOI: 10.1177/34.1.2416801. View

19.

Loskutoff D . Effect of thrombin on the fibrinolytic activity of cultured bovine endothelial cells. J Clin Invest. 1979; 64(1):329-32. PMC: 372122. DOI: 10.1172/JCI109457. View

20.

Zetter B . The endothelial cells of large and small blood vessels. Diabetes. 1981; 30(Suppl 2):24-8. DOI: 10.2337/diab.30.2.s24. View