Broad-spectrum Antiviral Therapeutics

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Aug 6

PMID 21818340

Citations 25

Authors

Todd H Rider

Christina E Zook

Tara L Boettcher

Scott T Wick

Jennifer S Pancoast

Benjamin D Zusman

Affiliations

Soon will be listed here.

Abstract

Currently there are relatively few antiviral therapeutics, and most which do exist are highly pathogen-specific or have other disadvantages. We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces apoptosis in cells containing viral dsRNA, rapidly killing infected cells without harming uninfected cells. We have created DRACOs and shown that they are nontoxic in 11 mammalian cell types and effective against 15 different viruses, including dengue flavivirus, Amapari and Tacaribe arenaviruses, Guama bunyavirus, and H1N1 influenza. We have also demonstrated that DRACOs can rescue mice challenged with H1N1 influenza. DRACOs have the potential to be effective therapeutics or prophylactics for numerous clinical and priority viruses, due to the broad-spectrum sensitivity of the dsRNA detection domain, the potent activity of the apoptosis induction domain, and the novel direct linkage between the two which viruses have never encountered.

Citing Articles

Recent Patents and FDA-Approved Drugs Based on Antiviral Peptides and Other Peptide-Related Antivirals.

Sadat Mousavi Maleki M, Sardari S, Ghandehari Alavijeh A, Madanchi H Int J Pept Res Ther. 2022; 29(1):5.

PMID: 36466430 PMC: 9702942. DOI: 10.1007/s10989-022-10477-z.

Apoptosis during ZIKA Virus Infection: Too Soon or Too Late?.

Turpin J, El Safadi D, Lebeau G, Krejbich M, Chatelain C, Despres P Int J Mol Sci. 2022; 23(3).

PMID: 35163212 PMC: 8835863. DOI: 10.3390/ijms23031287.

Human coronaviruses and therapeutic drug discovery.

Song L, Xie Q, Lao H, Lv Z Infect Dis Poverty. 2021; 10(1):28.

PMID: 33726861 PMC: 7962087. DOI: 10.1186/s40249-021-00812-9.

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications.

Ivanisenko N, Seyrek K, Kolchanov N, Ivanisenko V, Lavrik I Cell Death Discov. 2020; 6(1):101.

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Approaches and advances in the development of potential therapeutic targets and antiviral agents for the management of SARS-CoV-2 infection.

Krishna G, Pillai V, Veettil M Eur J Pharmacol. 2020; 885:173450.

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