Pathways Underlying the Gut-to-brain Connection in Autism Spectrum Disorders As Future Targets for Disease Management

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 2011 Aug 4

PMID 21810417

Citations 68

Authors

Caroline G M de Theije

Jiangbo Wu

Sofia Lopes da Silva

Patrick J Kamphuis

Johan Garssen

S Mechiel Korte

Aletta D Kraneveld

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.

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