Targeting N-acetylglucosamine-bearing Polymer-coated Liposomes to Vascular Smooth Muscle Cells

Overview

Journal J Artif Organs

Specialty Biomedical Engineering

Date 2011 Aug 3

PMID 21809097

Citations 4

Authors

Mamiko Ise

Hirohiko Ise

Yuji Shiba

Satoshi Kobayashi

Mitsuaki Goto

Masafumi Takahashi

Toshihiro Akaike

Uichi Ikeda

Affiliations

Soon will be listed here.

Abstract

The targeted delivery of anti-inflammatory agents has great therapeutic potential for treating restenosis following percutaneous coronary intervention. To develop a drug delivery system targeted to injured blood vessels, we examined whether N-acetylglucosamine (GlcNAc)-bearing polymer-coated liposomes (GlcNAc-Ls) are specifically taken up by vascular smooth muscle cells (VSMCs). Flow cytometric analysis revealed that GlcNAc-Ls were taken up by VSMCs in vitro. Furthermore, GlcNAc-Ls were intravenously administered to mice that had undergone wire-mediated vascular injury. GlcNAc-Ls markedly accumulated at the intramural site of the injured vessel walls but not at the contralateral (uninjured) vessel walls. These results demonstrated that GlcNAc-Ls can be specifically taken up by VSMCs both in vitro and in vivo. We propose a novel strategy of using GlcNAc-Ls that has potential for application in drug delivery targeted to injured blood vessels.

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