Common Variation at 10p12.31 Near MLLT10 Influences Meningioma Risk

Overview

Journal Nat Genet

Specialty Genetics

Date 2011 Aug 2

PMID 21804547

Citations 33

Authors

Sara E Dobbins

Peter Broderick

Beatrice Melin

Maria Feychting

Christoffer Johansen

Ulrika Andersson

Thomas Brannstrom

Johannes Schramm

Bianca Olver

Amy Lloyd

Yussanne P Ma

Fay J Hosking

Stefan Lonn

Anders Ahlbom

Roger Henriksson

Minouk J Schoemaker

Sarah J Hepworth

Per Hoffmann

Thomas W Muhleisen

Markus M Nothen

Susanne Moebus

Lewin Eisele

Michael Kosteljanetz

Kenneth Muir

Anthony Swerdlow

Matthias Simon

Richard S Houlston

Affiliations

Soon will be listed here.

Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

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