The Link Between Major Histocompatibility Complex Antibodies and Cell Proliferation

Overview

Journal Transplant Rev (Orlando)

Specialty General Surgery

Date 2011 Aug 2

PMID 21803559

Citations 9

Authors

Nicole M Valenzuela

Elaine F Reed

Affiliations

Soon will be listed here.

Abstract

Experimental evidence indicates that donor-specific antibodies targeting major histocompatibility complex classes I and II molecules can elicit the key features of transplant vasculopathy by acting on the graft vasculature in 3 ways: directly activating proliferative, prosurvival, and migratory signaling in the target endothelial and smooth muscle cells; increasing expression of mitogenic factors in vascular endothelial cells, creating a potential proliferative autocrine loop; and promoting recruitment of inflammatory cells that produce mitogenic factors and elicit chronic inflammation, proliferation, and fibrosis. Here, we review the experimental literature showing the complement and Fc-independent effects of major histocompatibility complex classes I and II antibodies on graft vascular cells that may directly contribute to the proliferative aspect of transplant vasculopathy.

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