Hematopoietic Stem and Progenitor Cell Trafficking

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2011 Aug 2

PMID 21802990

Citations 89

Authors

Irina B Mazo

Steffen Massberg

Ulrich H von Andrian

Affiliations

Soon will be listed here.

Abstract

Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.

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