Serum Selenium Levels Do Not Differ in Type 2 Diabetic Subjects with and Without Coronary Artery Disease

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2011 Aug 2

PMID 21801367

Citations 2

Authors

Alexios Sotiropoulos

Stavroula A Papadodima

Athanasia K Papazafiropoulou

Aggelos Ioannidis

Athanasia Kokkinari

Ourania Apostolou

Chara A Spiliopoulou

Sotirios Athanaselis

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD).

Methods: A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants.

Results: Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05).

Conclusion: Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

Citing Articles

Protective effects of paraoxonase-1, vitamin E and selenium, and oxidative stress index on the susceptibility of low density lipoprotein to oxidation in diabetic patients with/without coronary artery disease.

Mehvari F, Imanparast F, Mohaghegh P, Alimoradian A, Khansari N, Ansari Asl B Eur J Med Res. 2023; 28(1):300.

PMID: 37635255 PMC: 10464334. DOI: 10.1186/s40001-023-01254-9.

Increased selenium and decreased iron levels in relation to risk of coronary artery disease in patients with diabetes.

Tian M, Hu T, Ying J, Cui H, Huangfu N Front Nutr. 2023; 10:1103330.

PMID: 37275636 PMC: 10233138. DOI: 10.3389/fnut.2023.1103330.

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