The Role of Atg Proteins in Autophagosome Formation

Overview

Journal Annu Rev Cell Dev Biol

Publisher Annual Reviews

Specialty Cell Biology

Date 2011 Aug 2

PMID 21801009

Citations 1543

Authors

Noboru Mizushima

Tamotsu Yoshimori

Yoshinori Ohsumi

Affiliations

Soon will be listed here.

Abstract

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

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